TY - JOUR
T1 - Genesis of remote conditioning
T2 - Action at a distance-hypotheses non fingo?
AU - Przyklenk, Karin
AU - Whittaker, Peter
PY - 2013/3
Y1 - 2013/3
N2 - Remote ischemic preconditioning is the phenomenon whereby brief episodes of ischemia-reperfusion applied in a distant organ or tissue render the myocardium resistant to infarction. The discovery of remote conditioning was not a serendipitous finding, but, rather, was predicted by mathematical modeling. In the current review, we describe how the hypothesis for remote conditioning was formulated and tested, how the paradigm has expanded to encompass a spectrum of remote triggers, and summarize the progress that has been made in elucidating the mechanisms responsible for this intriguing form of cardioprotection.
AB - Remote ischemic preconditioning is the phenomenon whereby brief episodes of ischemia-reperfusion applied in a distant organ or tissue render the myocardium resistant to infarction. The discovery of remote conditioning was not a serendipitous finding, but, rather, was predicted by mathematical modeling. In the current review, we describe how the hypothesis for remote conditioning was formulated and tested, how the paradigm has expanded to encompass a spectrum of remote triggers, and summarize the progress that has been made in elucidating the mechanisms responsible for this intriguing form of cardioprotection.
KW - Cardioprotection
KW - Myocardial infarction
KW - Myocardial ischemia
KW - Remote ischemic preconditioning
UR - http://www.scopus.com/inward/record.url?scp=84874653794&partnerID=8YFLogxK
U2 - 10.2459/JCM.0b013e328358c8eb
DO - 10.2459/JCM.0b013e328358c8eb
M3 - Article
C2 - 22964648
AN - SCOPUS:84874653794
VL - 14
SP - 180
EP - 186
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 3
ER -