Global assays in hemophilia

Meera Chitlur, Guy Young

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

The quest for the ideal method to study hemostasis in the evaluation and management of patients with bleeding disorders such as hemophilia is an ongoing effort. With the rapid evolution of biotechnology and the emergence of several new products for treatment of patients with hemophilia with and without inhibitors, there is a great need for tests that can be used to reliably evaluate and monitor our interventions. Global assays in coagulation allow the study of the interaction between the components involved in the process of hemostasis and are therefore considered by many to be more reflective of the in vivo hemostatic mechanism. Here we provide a brief review of the most widely used global assays in hemostasis (thrombin generation and thromboelastography) and their utility in the evaluation and management of hemophilia.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalSeminars in Hematology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Global assays
  • Hemophilia
  • Hemostasis
  • Thrombin generation
  • Thromboelastography

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