Hematologic Abnormalities After Oral Trimethoprim-Sulfamethoxazole Therapy in Children

Basim I. Asmar, Sajid Maqbool, Adnan S. Dajani

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The development of hematologic abnormalities was prospectively evaluated in 50 children treated for ten days each with oral trimethoprim-sulfamethoxazole and compared with a control group of 20 children with similar infections treated with amoxicillin trihydrate. Neutropeniadeveloped in 17of the 50 children treated with trimethoprim-sulfamethoxazole compared with onein the control group of 20 children Thrombocytopenia (platelet count, < 150,000/cu mm) developed in six (12%) of the children treated with trimethoprim-sulfamethoxazole, but it did not develop in any of the amoxicillin-treated children (P <.01). Neutropenia occurred mostly during the first week of treatment and lasted a mean of 8.9 days. Thrombocytopenia was noted between the seventh and 16th day (mean, 10.3 days) and lasted a mean of 12.7 days. Both side effects resolved spontaneously without ill effects. Children treated with oral trimethoprim-sulfamethoxazole should be followed up with biweekly leukocyte and platelet counts, and treatment should be discontinued if severe neutropenia or thrombocytopenia develops.

Original languageEnglish
Pages (from-to)1100-1103
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume135
Issue number12
DOIs
StatePublished - Dec 1981

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