Herpes Simplex Virus Pneumonia in a Patient with Ependymoma

Hiroto Inaba, Raja Rabah, Kathleen L. Meert, Kanta BhamBhani

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The authors report a fatal outcome in a 4-year-old boy with herpes simplex virus (HSV) pneumonia and ependymoma. The patient had respiratory distress that worsened despite antibiotic treatment. Bronchoalveolar lavage showed intranuclear viral inclusions, and culture was positive for HSV type 1. His T-cell count was significantly decreased. Although acyclovir and foscamet were given, the patient died. Postmortem examination showed HSV pneumonitis with severe alveolar damage and severe involutional changes of the thymus with absence of Hassall's corpuscles. HSV must be considered in the differential diagnosis of patients with interstitial pneumonia and T-cell deficiency, especially after craniospinal irradiation.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number2
StatePublished - Feb 2004


  • Ependymoma
  • Herpes simplex virus
  • Pneumonia


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