TY - JOUR
T1 - Highly Efficient Photothermal Therapy with Cell-Penetrating Peptide-Modified Bumpy Au Triangular Nanoprisms using Low Laser Power and Low Probe Dose
AU - Ha, Minji
AU - Nam, So Hee
AU - Sim, Kyunjong
AU - Chong, Seung Eun
AU - Kim, Jiyeon
AU - Kim, Yuna
AU - Lee, Yan
AU - Nam, Jwa Min
N1 - Funding Information:
This work was supported by the BioNano Health-Guard Research Center funded by the Ministry of Science and ICT (MSIT) of Korea as Global Frontier Project (H-GUARD_2013-M3A6B2078947) and the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (NRF-2017R1A5A1015365 and NRF-2017M3A9E4077448).
Publisher Copyright:
©
PY - 2021/1/13
Y1 - 2021/1/13
N2 - Photothermal therapy (PTT) exploits nanomaterials with optimal heat conversion and cellular penetration using near-infrared (NIR) laser irradiation. However, current PTT agents suffer from inefficient heat conversion, poor intracellular delivery, and a high dose of probes along with excessive laser irradiation, causing limited therapeutic outcomes. Here, bumpy Au triangular nanoprisms (BATrisms) are developed for increasing the surface area, improving cell penetration, shifting the absorption peak to the NIR region, and enhancing the photothermal conversion efficiency (a86%). Further, leucine (L)- A nd lysine (K)-rich cell-penetrating peptides (LK peptides) were employed to largely improve their cellular uptake efficiency. Importantly, a significant in vivo therapeutic efficacy with LK-BATrisms was demonstrated in a triple-negative breast cancer xenograft mice model. A very small dose of LK-BATrism (2.5 μg Au) was enough to exert antitumor efficacy under very low laser power (808 nm, 0.25 W/cm2), causing minimal tissue damages while very efficiently killing cancer cells.
AB - Photothermal therapy (PTT) exploits nanomaterials with optimal heat conversion and cellular penetration using near-infrared (NIR) laser irradiation. However, current PTT agents suffer from inefficient heat conversion, poor intracellular delivery, and a high dose of probes along with excessive laser irradiation, causing limited therapeutic outcomes. Here, bumpy Au triangular nanoprisms (BATrisms) are developed for increasing the surface area, improving cell penetration, shifting the absorption peak to the NIR region, and enhancing the photothermal conversion efficiency (a86%). Further, leucine (L)- A nd lysine (K)-rich cell-penetrating peptides (LK peptides) were employed to largely improve their cellular uptake efficiency. Importantly, a significant in vivo therapeutic efficacy with LK-BATrisms was demonstrated in a triple-negative breast cancer xenograft mice model. A very small dose of LK-BATrism (2.5 μg Au) was enough to exert antitumor efficacy under very low laser power (808 nm, 0.25 W/cm2), causing minimal tissue damages while very efficiently killing cancer cells.
KW - LK peptides
KW - bumpy Au triangular nanoprism
KW - cell-penetrating peptides
KW - photothermal therapy
KW - plasmonic nanoprobes
UR - http://www.scopus.com/inward/record.url?scp=85098772753&partnerID=8YFLogxK
U2 - 10.1021/acs.nanolett.0c04386
DO - 10.1021/acs.nanolett.0c04386
M3 - Article
C2 - 33332127
AN - SCOPUS:85098772753
SN - 1530-6984
VL - 21
SP - 731
EP - 739
JO - Nano Letters
JF - Nano Letters
IS - 1
ER -
