Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan

Darren Story, John Gallien, Abeer Al-Gharaibeh, Michael Sandstrom, Julien Rossignol, Gary L. Dunbar

Research output: Contribution to journalArticlepeer-review


The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalJournal of Huntington's Disease
Issue number4
StatePublished - 2021


  • Huntington's disease
  • R6/2
  • environmental enrichment
  • housing
  • survivability


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