TY - JOUR
T1 - Housing R6/2 mice with wild-type littermates increases lifespan
AU - Story, Darren
AU - Sandstrom, Michael I
AU - Rossignol, Julien Pierre Andre
AU - Dunbar, Gary
N1 - Funding Information:
The authors would like to thank Veronica Wilson for her assistance with animal care and monitoring throughout the course of this study. Funding for this project was provided by the Field Neurosciences Institute and the John G. Kulhavi Professorship in Neuroscience.
Publisher Copyright:
© 2021 - IOS Press. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.
AB - The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.
UR - https://doi.org/10.3233/JHD-210474
M3 - Article
VL - 10
SP - 455
EP - 458
JO - Journal of Huntington's Disease
JF - Journal of Huntington's Disease
SN - 1879-6397
IS - 4
ER -