Human Cytomegalovirus-Induced Interleukin-10 Production Promotes the Proliferation of Mycobacterium massiliense in Macrophages

Hailian Quan, Jiyeon Kim, Yi Rang Na, Jung Heon Kim, Byoung Jun Kim, Bum Joon Kim, Jung Joo Hong, Eung Soo Hwang, Seung Hyeok Seok

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1 Scopus citations

Abstract

Human cytomegalovirus (HCMV) exploits the interleukin-10 (IL-10) pathway as a part of its infection cycle through the manipulation of the host IL-10 signaling cascade. Based on its immunomodulatory nature, HCMV attenuates the host immune response and facilitates the progression of co-infection with other pathogens in an immune-competent host. To investigate the impact of HCMV infection on the burden of non-tuberculous mycobacteria (NTM), whose prevalence is growing rapidly worldwide, macrophages were infected with HCMV and further challenged with Mycobacterium massiliense in vitro. The results showed that HCMV infection significantly increased host IL-10 synthesis and promoted the proliferation of M. massiliense in an IL-10-dependent manner. Transcriptomic analysis revealed that HCMV infection dampened the regulatory pathways of interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin-1 (IL-1), consequently abrogating the immune responses to M. massiliense coinfection in macrophages. These findings provide a mechanistic basis of how HCMV infection may facilitate the development of pathogenic NTM co-infection by upregulating IL-10 expression.

Original languageEnglish
Article number518605
JournalFrontiers in Immunology
Volume11
DOIs
StatePublished - Sep 10 2020

Keywords

  • Mycobacterium massiliense
  • human cytomegalovirus
  • interleukin-10
  • macrophage
  • non-tuberculous mycobacteria

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