Humoral Immune Deficiencies of Childhood

Marwa El-Bohy, Pavadee Poowuttikul, Elizabeth Secord

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The most common primary immune deficiencies are those of the humoral immune system, and most of these present in childhood. The severity of these disorders ranges from transient deficiencies to deficiencies that are associated with a complete loss of ability to make adequate or functional antibodies, and have infectious as well as noninfectious complications. This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects.

Original languageEnglish
Pages (from-to)897-903
Number of pages7
JournalPediatric Clinics of North America
Issue number5
StatePublished - Oct 2019


  • Antibody deficiency
  • B cell deficiency
  • Humoral immune deficiency
  • Immunoglobulin deficiency


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