TY - JOUR
T1 - Humoral Immune Deficiencies of Childhood
AU - El-Bohy, Marwa
AU - Poowuttikul, Pavadee
AU - Secord, Elizabeth
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - The most common primary immune deficiencies are those of the humoral immune system, and most of these present in childhood. The severity of these disorders ranges from transient deficiencies to deficiencies that are associated with a complete loss of ability to make adequate or functional antibodies, and have infectious as well as noninfectious complications. This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects.
AB - The most common primary immune deficiencies are those of the humoral immune system, and most of these present in childhood. The severity of these disorders ranges from transient deficiencies to deficiencies that are associated with a complete loss of ability to make adequate or functional antibodies, and have infectious as well as noninfectious complications. This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects.
KW - Antibody deficiency
KW - B cell deficiency
KW - Humoral immune deficiency
KW - Immunoglobulin deficiency
UR - http://www.scopus.com/inward/record.url?scp=85071106009&partnerID=8YFLogxK
U2 - 10.1016/j.pcl.2019.06.010
DO - 10.1016/j.pcl.2019.06.010
M3 - Review article
C2 - 31466679
AN - SCOPUS:85071106009
SN - 0031-3955
VL - 66
SP - 897
EP - 903
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
IS - 5
ER -