Hypochlorous acid for accidental vincristine overdose: A preliminary experimental study

U. Ozgen, M. Stout, Y. Turkoz, F. Ozugurlu, N. O. Kutlu, H. Soylu, U. Koltuksuz, B. Mizrak, E. Sonmezgoz, C. Ozcan, Y. Ravindranath, S. Savasan

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalExperimental Oncology
Volume25
Issue number4
StatePublished - Dec 2003

Keywords

  • Experimental animals
  • Hypochlorous acid
  • Neurotoxicity
  • Vincristine overdose

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