TY - JOUR
T1 - Hypochlorous acid for accidental vincristine overdose
T2 - A preliminary experimental study
AU - Ozgen, U.
AU - Stout, M.
AU - Turkoz, Y.
AU - Ozugurlu, F.
AU - Kutlu, N. O.
AU - Soylu, H.
AU - Koltuksuz, U.
AU - Mizrak, B.
AU - Sonmezgoz, E.
AU - Ozcan, C.
AU - Ravindranath, Y.
AU - Savasan, S.
PY - 2003/12
Y1 - 2003/12
N2 - Aim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.
AB - Aim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.
KW - Experimental animals
KW - Hypochlorous acid
KW - Neurotoxicity
KW - Vincristine overdose
UR - http://www.scopus.com/inward/record.url?scp=0742271089&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0742271089
VL - 25
SP - 298
EP - 300
JO - Experimental Oncology
JF - Experimental Oncology
SN - 0204-3564
IS - 4
ER -