TY - JOUR
T1 - Hypothermia for neonatal hypoxic–ischemic encephalopathy
T2 - NICHD Neonatal Research Network contribution to the field
AU - Shankaran, Seetha
AU - Natarajan, Girija
AU - Chalak, Lina
AU - Pappas, Athina
AU - McDonald, Scott A.
AU - Laptook, Abbot R.
N1 - Funding Information:
Supported by Grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Neonatal Research Network.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.
AB - In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.
KW - Biomarkers
KW - Hypothermia Neuroprotection
KW - Hypoxic-ischemic encephalopathy
KW - Neonatal
UR - http://www.scopus.com/inward/record.url?scp=84992327126&partnerID=8YFLogxK
U2 - 10.1053/j.semperi.2016.05.009
DO - 10.1053/j.semperi.2016.05.009
M3 - Article
C2 - 27345952
AN - SCOPUS:84992327126
VL - 40
SP - 385
EP - 390
JO - Seminars in Perinatology
JF - Seminars in Perinatology
SN - 0146-0005
IS - 6
ER -