Impact of creatine on muscle performance and phosphagen stores after immobilization

Jeremy C. Fransen, Micah Zuhl, Chad M. Kerksick, Nathan Cole, Steve Altobelli, Dean O. Kuethe, Suzanne Schneider

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Purpose: This study investigated the effect of creatine (CR) supplementation during cast-immobilization to preserve skeletal muscle total work, power and intramuscular phosphocreatine (PCr) kinetics during dynamic exercise. Methods: Twenty-five active individuals (24 ± 4 years,) performed wrist flexion exercise within a 1.9 Tesla superconducting magnet before and after 1 week of cast-immobilization. An incremental protocol to fatigue and two constant load (CL1 and CL2) exercise bouts were performed. While casted, participants consumed either 20 g day−1 of CR or a placebo (PLA). 31P magnetic resonance spectroscopy was used to quantify in vivo intramuscular PCr levels. Results: No significant group × time interaction effects were found for work or power throughout all exercise bouts. Total work was significantly reduced over time in both groups (p = 0.049) during the incremental exercise bout. Work production in CL1 tended (p = 0.073) to attenuate in the CR group, compared to PLA. No changes were observed in CL2. Baseline PCr significantly decreased with casting in PLA (PRE: 26.6 ± 6.3 vs. POST: 22.5 ± 5.6 mM kg−1 wet muscle, p = 0.003). No change (p = 0.31) was observed in the CR group. Changes in work production were significantly correlated with changes in resting PCr in CR (r = −0.63, p = 0.021) but not PLA (r = −0.36, p = 0.26) group. Conclusions: Results suggest decreases in short-term endurance may be due to alternations of PCr status and/or metabolism. More research is needed to fully determine the efficacy of CR supplementation during short-term immobilization.

Original languageEnglish
Pages (from-to)1877-1886
Number of pages10
JournalEuropean Journal of Applied Physiology
Issue number9
StatePublished - Sep 17 2015


  • Casting
  • Creatine phosphate
  • Muscle endurance
  • P MRS


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