TY - JOUR
T1 - Impact of pregnancy marijuana use on birth outcomes
T2 - results from two matched population-based cohorts
AU - Bailey, Beth A.
AU - Wood, David L.
AU - Shah, Darshan
N1 - Funding Information:
Funding The Tennessee site portion of the study was funded in part by a grant from the Johnson City Junior League, and in-kind contributions from the Departments of Pediatrics and Family Medicine, and the Center for Prescription Drug Abuse and Misuse, at East Tennessee State University.. The Colorado site portion of the study was funded in part by support from the Department of Obstetrics and Gynecology, University of Colorado. None of the funding agencies had any role in the conduct of the study nor the interpretation of the findings.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Objective: To examine associations between in utero marijuana exposure and birth outcomes. Study design: In two separate cohorts (Appalachian, Rocky Mountain), data were collected from medical records. Marijuana exposure was positive based on urine drug screening at delivery, with nonexposed controls matched on multiple factors including other substance exposure. Result: Marijuana-exposed newborns (n = 531) had significantly worse birth outcomes than controls (n = 531), weighing 218 g less, 82%, 79%, and 43% more likely to be low birth weight, preterm, or admitted to the NICU, respectively, and significantly lower Apgar scores. Conclusion: Marijuana exposure in utero predicted newborn factors linked to longer-term health and development issues. Effects were not attributable to other comorbidities in this study due to rigorous matching and biochemical verification of marijuana and other drug use. Findings add to growing evidence linking marijuana exposure to adverse birth and longer-term outcomes. Women should be encouraged to avoid marijuana use during pregnancy.
AB - Objective: To examine associations between in utero marijuana exposure and birth outcomes. Study design: In two separate cohorts (Appalachian, Rocky Mountain), data were collected from medical records. Marijuana exposure was positive based on urine drug screening at delivery, with nonexposed controls matched on multiple factors including other substance exposure. Result: Marijuana-exposed newborns (n = 531) had significantly worse birth outcomes than controls (n = 531), weighing 218 g less, 82%, 79%, and 43% more likely to be low birth weight, preterm, or admitted to the NICU, respectively, and significantly lower Apgar scores. Conclusion: Marijuana exposure in utero predicted newborn factors linked to longer-term health and development issues. Effects were not attributable to other comorbidities in this study due to rigorous matching and biochemical verification of marijuana and other drug use. Findings add to growing evidence linking marijuana exposure to adverse birth and longer-term outcomes. Women should be encouraged to avoid marijuana use during pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=85081630439&partnerID=8YFLogxK
U2 - 10.1038/s41372-020-0643-z
DO - 10.1038/s41372-020-0643-z
M3 - Article
C2 - 32139807
AN - SCOPUS:85081630439
VL - 40
SP - 1477
EP - 1482
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 10
ER -