Impaired oxidative metabolism of salicylate in Reye's syndrome

K. L. Meert, R. E. Kauffman, D. R. Deshmukh, A. P. Sarnaik

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Administration of salicylates during prodromal viral illness has been associated with the development of Reye's Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalDevelopmental Pharmacology and Therapeutics
Volume15
Issue number2
DOIs
StatePublished - 1990

Keywords

  • Reye's syndrome
  • oxidative metabolism
  • salicylate

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