Impaired oxidative metabolism of salicylate in Reye's syndrome

K. L. Meert; R. E. Kauffman; D. R. Deshmukh; A. P. Sarnaik

doi:10.1159/000457622

Impaired oxidative metabolism of salicylate in Reye's syndrome

K. L. Meert, R. E. Kauffman, D. R. Deshmukh, A. P. Sarnaik

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Abstract

Administration of salicylates during prodromal viral illness has been associated with the development of Reye's Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	Developmental Pharmacology and Therapeutics
Volume	15
Issue number	2
DOIs	https://doi.org/10.1159/000457622
State	Published - 1990

Keywords

Reye's syndrome
oxidative metabolism
salicylate

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10.1159/000457622

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title = "Impaired oxidative metabolism of salicylate in Reye's syndrome",

abstract = "Administration of salicylates during prodromal viral illness has been associated with the development of Reye's Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.",

keywords = "Reye's syndrome, oxidative metabolism, salicylate",

author = "Meert, {K. L.} and Kauffman, {R. E.} and Deshmukh, {D. R.} and Sarnaik, {A. P.}",

year = "1990",

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T1 - Impaired oxidative metabolism of salicylate in Reye's syndrome

AU - Meert, K. L.

AU - Kauffman, R. E.

AU - Deshmukh, D. R.

AU - Sarnaik, A. P.

PY - 1990

Y1 - 1990

N2 - Administration of salicylates during prodromal viral illness has been associated with the development of Reye's Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.

AB - Administration of salicylates during prodromal viral illness has been associated with the development of Reye's Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.

KW - Reye's syndrome

KW - oxidative metabolism

KW - salicylate

UR - http://www.scopus.com/inward/record.url?scp=0025667974&partnerID=8YFLogxK

U2 - 10.1159/000457622

DO - 10.1159/000457622

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AN - SCOPUS:0025667974

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VL - 15

SP - 57

EP - 60

JO - Developmental Pharmacology and Therapeutics

JF - Developmental Pharmacology and Therapeutics

IS - 2

ER -

Impaired oxidative metabolism of salicylate in Reye's syndrome

Abstract

Keywords

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