TY - JOUR
T1 - In-hospital mortality and morbidity among extremely preterm infants in relation to maternal body mass index
AU - for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network
AU - Chawla, Sanjay
AU - Laptook, Abbot R.
AU - Smith, Emily A.
AU - Tan, Sylvia
AU - Natarajan, Girija
AU - Wyckoff, Myra H.
AU - Ambalavanan, Namasivayam
AU - Bell, Edward F.
AU - Van Meurs, Krisa P.
AU - Stevenson, David K.
AU - Werner, Erika F.
AU - Greenberg, Rachel G.
AU - Das, Abhik
AU - Shankaran, Seetha
N1 - Funding Information:
Funding Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA (UG1HD27904, UG1HD21364, U10HD68284, UG1HD27853, UL1TR77, UG1HD40492, UL1TR1117, UL1TR1111, UG1HD27851, UL1TR454, U10HD27856, UL1TR6, UG1HD87229, U10HD68278, U10 HD36790, UG1HD27880, UL1TR93, UG1 HD34216, U10HD68270, UG1HD53109, M01RR59, UL1TR442, UG1HD53089, UL1TR41, UG1HD68244, UG1HD68-263, UL1TR42, UG1HD40689, UG1HD87226, UL1TR105, and U10HD21385).
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Objective: The objective of this paper is to compare in-hospital survival and survival without major morbidities in extremely preterm infants in relation to maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–286/7 weeks). This study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. Primary outcome was survival without any major morbidity. Results: Maternal BMI data were available for 2415 infants. Survival without any major morbidity was not different between groups: 30.8% in the underweight/normal, 28.1% in the overweight, and 28.5% in the obese (P = 0.65). However, survival was lower in the obese group (76.5%) compared with overweight group (83.2%) (P = 0.02). Each unit increase in maternal BMI was associated with decreased odds of infant survival (P < 0.01). Conclusions: Survival without any major morbidity was not associated with maternal obesity. An increase in maternal prepregnancy BMI was associated with decreased odds of infant survival.
AB - Objective: The objective of this paper is to compare in-hospital survival and survival without major morbidities in extremely preterm infants in relation to maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7–286/7 weeks). This study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. Primary outcome was survival without any major morbidity. Results: Maternal BMI data were available for 2415 infants. Survival without any major morbidity was not different between groups: 30.8% in the underweight/normal, 28.1% in the overweight, and 28.5% in the obese (P = 0.65). However, survival was lower in the obese group (76.5%) compared with overweight group (83.2%) (P = 0.02). Each unit increase in maternal BMI was associated with decreased odds of infant survival (P < 0.01). Conclusions: Survival without any major morbidity was not associated with maternal obesity. An increase in maternal prepregnancy BMI was associated with decreased odds of infant survival.
UR - http://www.scopus.com/inward/record.url?scp=85092190599&partnerID=8YFLogxK
U2 - 10.1038/s41372-020-00847-0
DO - 10.1038/s41372-020-00847-0
M3 - Article
C2 - 33024258
AN - SCOPUS:85092190599
SN - 0743-8346
VL - 41
SP - 1014
EP - 1024
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 5
ER -