In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

Prashant Agarwal, Deniz Altinok, Jagdish Desai, Christina Shanti, Girija Natarajan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO). Study design: Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN). Results: Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. During ECMO, 30% (n = 6) infants developed intracranial hemorrhage at a median (IQR) duration of 24 (20) hours. Sixteen (80%) infants survived to discharge, among which 15 had MRI performed; 47% (n = 7) had normal MRI, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had NICHD stage 1, 2, and 3 pattern of brain injury respectively. Conclusions: In this high-risk population of neonates, use of ECMO was safe and efficacious as demonstrated by survival and outcomes.

Original languageEnglish
Pages (from-to)661-665
Number of pages5
JournalJournal of Perinatology
Volume39
Issue number5
DOIs
StatePublished - May 1 2019

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