TY - JOUR
T1 - In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation
AU - Agarwal, Prashant
AU - Altinok, Deniz
AU - Desai, Jagdish
AU - Shanti, Christina
AU - Natarajan, Girija
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Objective: To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO). Study design: Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN). Results: Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. During ECMO, 30% (n = 6) infants developed intracranial hemorrhage at a median (IQR) duration of 24 (20) hours. Sixteen (80%) infants survived to discharge, among which 15 had MRI performed; 47% (n = 7) had normal MRI, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had NICHD stage 1, 2, and 3 pattern of brain injury respectively. Conclusions: In this high-risk population of neonates, use of ECMO was safe and efficacious as demonstrated by survival and outcomes.
AB - Objective: To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO). Study design: Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN). Results: Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. During ECMO, 30% (n = 6) infants developed intracranial hemorrhage at a median (IQR) duration of 24 (20) hours. Sixteen (80%) infants survived to discharge, among which 15 had MRI performed; 47% (n = 7) had normal MRI, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had NICHD stage 1, 2, and 3 pattern of brain injury respectively. Conclusions: In this high-risk population of neonates, use of ECMO was safe and efficacious as demonstrated by survival and outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85062590235&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0345-6
DO - 10.1038/s41372-019-0345-6
M3 - Article
C2 - 30842551
AN - SCOPUS:85062590235
SN - 0743-8346
VL - 39
SP - 661
EP - 665
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 5
ER -