Induction of BCL2-interacting killer, BIK, is mediated for anti-cancer activity of curcumin in human head and neck squamous cell carcinoma cells

Yue Xi, Hang Gao, Michael U. Callaghan, Andrew M. Fribley, Danielle M. Garshott, Zhi Xiang Xu, Qinghua Zeng, Yu Lin Li

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Naturally occurring diarylheptanoid curcumin (CUR), a principal component of the Asian spice turmeric, has been shown to have anti-cancer effects in many tumor types. However, a detailed mechanism regarding CUR induced tumor cell killing remain to be comprehensively explored. Using two head neck squamous cell carcinoma (HNSCC) cell lines FaDu (hypopharyngeal) and Cal27 (tongue), we demonstrated a novel mechanism by which CUR levies the cytotoxic effect. We found that CUR induced upregulation of pro-apoptotic Bik, down-regulation of survival signaling by AKT and NF-κB prior to the induction of the caspase-cascade reduction of cell proliferation, are primary mechanisms of CUR-induced cell death, thus providing insights into the anti-tumor activity of CUR in HNSCC cells.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalJournal of Cancer
Volume6
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Dive into the research topics of 'Induction of BCL2-interacting killer, BIK, is mediated for anti-cancer activity of curcumin in human head and neck squamous cell carcinoma cells'. Together they form a unique fingerprint.

Cite this