TY - JOUR
T1 - Inflammation and aging
T2 - Can endocannabinoids help?
AU - Marchalant, Yannick
AU - Brothers, Holly M.
AU - Wenk, Gary L.
PY - 2008/4
Y1 - 2008/4
N2 - Aging often leads to cognitive decline due to neurodegenerative process in the brain. As people live longer, there exists a growing concern linked to long-term, slowly debilitating diseases, such as Alzheimer's disease for which a cure has not yet been found. Recently, the role of neuroinflammation has attracted attention due to its slow onset, chronic nature and its possible role in the development of many different neurodegenerative diseases. In the future, treatment of chronic neuroinflammation may help counteract aspects of neurodegenerative disease. Our recent studies have focused upon the endocannabinoid system for its unique effects on the expression of neuroinflammation. The basis for the manipulation of the endocannabinoid system in the brain in combination with existing treatments for Alzheimer's disease will be discussed in this review.
AB - Aging often leads to cognitive decline due to neurodegenerative process in the brain. As people live longer, there exists a growing concern linked to long-term, slowly debilitating diseases, such as Alzheimer's disease for which a cure has not yet been found. Recently, the role of neuroinflammation has attracted attention due to its slow onset, chronic nature and its possible role in the development of many different neurodegenerative diseases. In the future, treatment of chronic neuroinflammation may help counteract aspects of neurodegenerative disease. Our recent studies have focused upon the endocannabinoid system for its unique effects on the expression of neuroinflammation. The basis for the manipulation of the endocannabinoid system in the brain in combination with existing treatments for Alzheimer's disease will be discussed in this review.
KW - Aging
KW - Alzheimer's disease
KW - Cannabinoids
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=43049149810&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2008.02.004
DO - 10.1016/j.biopha.2008.02.004
M3 - Article
C2 - 18400455
AN - SCOPUS:43049149810
SN - 0753-3322
VL - 62
SP - 212
EP - 217
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - 4
ER -