TY - JOUR
T1 - Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules
AU - Webb, Tonja J.Roberts
AU - Litavecz, Roberta A.
AU - Khan, Masood A.
AU - Du, Wenjun
AU - Gervay-Hague, Jacquelyn
AU - Renukaradhya, Gourapura J.
AU - Brutkiewicz, Randy R.
PY - 2006/10
Y1 - 2006/10
N2 - Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
AB - Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
KW - Antigen presentation
KW - CD1d
KW - Immune evasion
KW - NKT cells
KW - Vaccinia virus
UR - http://www.scopus.com/inward/record.url?scp=33750227454&partnerID=8YFLogxK
U2 - 10.1002/eji.200636024
DO - 10.1002/eji.200636024
M3 - Article
C2 - 16981180
AN - SCOPUS:33750227454
SN - 0014-2980
VL - 36
SP - 2595
EP - 2600
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 10
ER -
