@article{9417d73733bc485480bf1f120a038a59,
title = "Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model",
abstract = "The recently developed human norovirus (HuNoV) B cell culture and mouse models hold promise for drug discovery and development but their suitability for antiviral studies has not been assessed. We demonstrate the inhibitory effect of the nucleoside analogue 2′-C-methylcytidine (2CMC) on HuNoV replication in the human B cell BJAB cell line and in Balb/c Rag/gamma chain-deficient (Rag-γc-/-) mice. These data suggest the applicability of both models for future study and development of antiviral drugs for the treatment of HuNoV infections.",
keywords = "Antiviral, Enteric virus, Human norovirus, Polymerase inhibitor, Positive-sense RNA virus",
author = "Kolawole, {Abimbola O.} and Joana Rocha-Pereira and Elftman, {Michael D.} and Johan Neyts and Wobus, {Christiane E.}",
note = "Funding Information: This work was supported in part by NIH grants R01 AI080611 and R21 AI110907 to CEW, by the Belgian Science Policy IUAP Interuniversity Attraction Poles (IAP) VII – P7/45 grant and KU Leuven IOF project HB/14/031 to JN. JRP is a Marie Curie COFUND William Harvey International Translational Research Academy (WHRI-ACADEMY #343) Postdoctoral Fellow. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = aug,
day = "1",
doi = "10.1016/j.antiviral.2016.05.011",
language = "English",
volume = "132",
pages = "46--49",
journal = "Antiviral Research",
issn = "0166-3542",
}