In vitro biodegradation, electrochemical corrosion evaluations and mechanical properties of an Mg/HA/TiO2nanocomposite for biomedical applications

Shahrouz Zamani Khalajabadi, Norhayati Ahmad, Sudin Izman, Aminudin Bin Haji Abu, Waseem Haider, Mohammed Rafiq Abdul Kadir

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

In this study, a biodegradable Mg/HA/TiO2nanocomposite was prepared using a milling-pressing-sintering powder metallurgy technique. The combined effects of hydroxyapatite (HA) and titania (TiO2) on the corrosion behavior of pure Mg were investigated via in vitro immersion and electrochemical tests in a simulated body fluid (SBF), and changes in the mechanical properties were analyzed using a compression test. Furthermore, X-ray diffraction, Fourier-transform infrared spectroscopy, atomic-force microscopy, field-emission scanning electron microscopy and transmission electron microscopy were used to investigate the composition and microstructure of the Mg/HA/TiO2bionanocomposite as well as the morphology of the corrosion products. The corrosion rate of the Mg/HA nanocomposite decreased both in terms of mass loss and hydrogen evolution with a decrease in HA from 27.5 to 5 wt% and an addition of 15 wt% TiO2. By sintering the Mg/HA/TiO2nanocomposites, MgTiO3nanoflakes were formed with a hierarchical microstructure on the surface of the samples. The compression and electrochemical tests indicated that the ternary Mg/12.5HA/10TiO2nanocomposite had a good combination of mechanical properties and corrosion resistance of 12.17 kΩ cm2in the SBF solution. The cell culture results indicated that the Mg/HA/TiO2nanocomposite was biocompatible with osteoblasts.

Original languageEnglish
Pages (from-to)768-781
Number of pages14
JournalJournal of Alloys and Compounds
Volume696
DOIs
StatePublished - 2017

Keywords

  • Biodegradation
  • Cell culture
  • Contact angle
  • Mechanical properties
  • Mg/HA/TiOnanocomposite
  • Nanoflakes

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