TY - JOUR
T1 - Isolation and characterization of the mouse homolog of the preprodynorphin (Pdyn) gene
AU - Sharifi, N.
AU - Ament, M.
AU - Brennan, M. B.
AU - Hochgeschwender, U.
PY - 1999/6
Y1 - 1999/6
N2 - We have isolated and sequenced the mouse preprodynorphin gene (Pdyn). The Pdyn gene can encode for six biologically active dynorphin peptides. The predicted mouse preprodynorphin has 90%, 67%, and 66% identity with the predicted rat, porcine, and human preprodynorphins, respectively. Using an RT-PCR technique, we show that the Pdyn gene starts being expressed at embryonic day 12.5, with a steep increase of expression by embryonic day 14.5; in the adult mouse it is expressed in the brain, but not in liver, heart, spleen, or kidney.
AB - We have isolated and sequenced the mouse preprodynorphin gene (Pdyn). The Pdyn gene can encode for six biologically active dynorphin peptides. The predicted mouse preprodynorphin has 90%, 67%, and 66% identity with the predicted rat, porcine, and human preprodynorphins, respectively. Using an RT-PCR technique, we show that the Pdyn gene starts being expressed at embryonic day 12.5, with a steep increase of expression by embryonic day 14.5; in the adult mouse it is expressed in the brain, but not in liver, heart, spleen, or kidney.
UR - http://www.scopus.com/inward/record.url?scp=0032793579&partnerID=8YFLogxK
U2 - 10.1054/npep.1999.0023
DO - 10.1054/npep.1999.0023
M3 - Article
C2 - 10657497
AN - SCOPUS:0032793579
SN - 0143-4179
VL - 33
SP - 236
EP - 238
JO - Neuropeptides
JF - Neuropeptides
IS - 3
ER -