TY - JOUR
T1 - Left ventricular diastolic function influences right ventricular — Pulmonary vascular coupling in premature infants
AU - Bussmann, Neidin
AU - EL-Khuffash, Afif
AU - Breatnach, Colm R.
AU - McCallion, Naomi
AU - Franklin, Orla
AU - Singh, Gautam K.
AU - Levy, Philip T.
N1 - Funding Information:
Dr. Levy and Dr. Singh have received grants from Prematurity and Respiratory Outcomes Program (NIH 1U01 HL1014650, U01 HL101794). Prof EL-Khuffash has received the following grants: EU FP7/2007–2013 grant (agreement no. 260777, The HIP Trial), the Friends of the Rotunda Research Grant (reference: FoR/EQUIPMENT/101572), Health Research Board Mother and Baby Clinical Trials Network Ireland (CTN-2014-10) and Temple Street Hospital Foundation (Grant Reference RPAC 16-03). Dr. Neidin Bussmann has received a postgraduate degree support grant from the National Children's Research Centre, Dublin, Ireland.
Funding Information:
Dr. Levy and Dr. Singh have received grants from Prematurity and Respiratory Outcomes Program ( NIH 1U01 HL1014650 , U01 HL101794 ). Prof EL-Khuffash has received the following grants: EU FP7/2007–2013 grant (agreement no. 260777 , The HIP Trial), the Friends of the Rotunda Research Grant (reference: FoR/EQUIPMENT/101572 ), Health Research Board Mother and Baby Clinical Trials Network Ireland ( CTN-2014-10 ) and Temple Street Hospital Foundation (Grant Reference RPAC 16-03 ). Dr. Neidin Bussmann has received a postgraduate degree support grant from the National Children's Research Centre , Dublin, Ireland.
Publisher Copyright:
© 2018
PY - 2019/1
Y1 - 2019/1
N2 - Introduction: Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV–pulmonary vasculature (PV) coupling. RV–PV can be assessed with the RV length–force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association between LV diastolic function measured using tissue Doppler imaging (TDI) and TAPSE/PAAT. Methods: A study of premature infants <29 weeks gestation. TAPSE/PAAT, LV e′ and a′ waves were measured on Day 1 following birth. Correlation between diastolic indices and TAPSE/PAAT was performed. The independent effect of LV diastolic function and TAPSE/PAAT was assessed using linear regression. Results: One hundred and sixty-two infants with a mean ± SD gestation & birthweight of 26.6 ± 1.5 weeks & 938 ± 241 g. There was a significant positive correlation between LV e′ (r = 0.44, p < 0.01)/LV a′ (r = 0.44, p < 0.01) and TAPSE/PAAT. This relationship remained significant when adjusting for important confounders (all p < 0.01). Infants with LV a′ values in the lowest quartile had lower TAPSE values (4.2 ± 1.2 vs. 5.1 ± 1.1 mm, p < 0.01) without a difference in PAAT (41 ± 8 vs. 41 ± 10 ms, p = 0.97). Conclusions: We observed a direct correlation between LV diastolic function and RV–PV coupling in the first day of age, highlighting the importance ventricular interdependence in premature infants. TAPSE/PAAT, as the index of the RV–PV interaction may be further explored for its potential to assess RV reserve under stress with preterm infants in health and disease.
AB - Introduction: Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV–pulmonary vasculature (PV) coupling. RV–PV can be assessed with the RV length–force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association between LV diastolic function measured using tissue Doppler imaging (TDI) and TAPSE/PAAT. Methods: A study of premature infants <29 weeks gestation. TAPSE/PAAT, LV e′ and a′ waves were measured on Day 1 following birth. Correlation between diastolic indices and TAPSE/PAAT was performed. The independent effect of LV diastolic function and TAPSE/PAAT was assessed using linear regression. Results: One hundred and sixty-two infants with a mean ± SD gestation & birthweight of 26.6 ± 1.5 weeks & 938 ± 241 g. There was a significant positive correlation between LV e′ (r = 0.44, p < 0.01)/LV a′ (r = 0.44, p < 0.01) and TAPSE/PAAT. This relationship remained significant when adjusting for important confounders (all p < 0.01). Infants with LV a′ values in the lowest quartile had lower TAPSE values (4.2 ± 1.2 vs. 5.1 ± 1.1 mm, p < 0.01) without a difference in PAAT (41 ± 8 vs. 41 ± 10 ms, p = 0.97). Conclusions: We observed a direct correlation between LV diastolic function and RV–PV coupling in the first day of age, highlighting the importance ventricular interdependence in premature infants. TAPSE/PAAT, as the index of the RV–PV interaction may be further explored for its potential to assess RV reserve under stress with preterm infants in health and disease.
UR - http://www.scopus.com/inward/record.url?scp=85056738582&partnerID=8YFLogxK
U2 - 10.1016/j.earlhumdev.2018.11.006
DO - 10.1016/j.earlhumdev.2018.11.006
M3 - Article
C2 - 30465910
AN - SCOPUS:85056738582
VL - 128
SP - 35
EP - 40
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
ER -