Light-stimulated destabilization of PEG-liposomes

Anja Mueller, Bruce Bondurant, David F. O'Brien

Research output: Contribution to journalConference articlepeer-review


The crosslinking polymerization of bis-substituted lipids in the presence of unreactive lipids causes the formation of lipid domains. This strategy is employed to destabilize PEG-liposomes. The crosslinking polymerization of bis-SorbPC with UV light in liposomes also containing cholesterol, DOPC or DSPC, and PEG-PE leads to controlled leakage of the encapsulated fluorescent dye. Because of the potentially damaging effect of UV light the polymerization of bis-SorbPC with visible light is more desirable. The successful polymerization and leakage of bis-SorbPC in PEG-liposomes with a photosensitizer and visible light.

Original languageEnglish
Pages (from-to)205-206
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Issue number2
StatePublished - Aug 1999


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