Long-term electrical stimulation-induced inhibition of partial epilepsy: Case report

Kost Elisevich, Ken Jenrow, Lori Schuh, Brien Smith

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The aim of this study was to determine the effects of long-term continuous cerebrocortical electrical stimulation in the treatment of partial epilepsy. The authors review the case of a 44-year-old man with medically intractable postencephalitic localization-related epilepsy with ictal onset in the primary motor cortex. For 5 years he was treated using patterned subthreshold electrical stimulation of the ictal site. This therapy has successfully eliminated the jacksonian march of cortical excitability and secondary generalization and reduced seizure frequency and intensity with an immediate postictal return of motor function. Over time, the seizure frequency subsided by more than 90%, with the patient showing no adverse features resulting from focal stimulation. The results in this case support the hypothesis that effective and safe long-term modulation of focal epilepsy is possible with focal cerebrocortical electrical stimulation.

Original languageEnglish
Pages (from-to)894-897
Number of pages4
JournalJournal of Neurosurgery
Volume105
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • Electrical stimulation
  • Measles encephalitis
  • Motor cortex

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