Low frequency of meperidine-associated seizures in sickle cell disease

Samina Z. Nadvi, Sharada Sarnaik, Yaddanapudi Ravindranath

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Pain control measures in sickle cell diseases are not uniform. Most clinicians use parenteral morphine or meperidine for severe pain. Reports of seizures associated with meperidine have led to a growing reliance on intravenous morphine, usually with patient-controlled devices. Acceptance of morphine has been poor among patients, and many prefer meperidine. The aim of this retrospective study was to determine the incidence of meperidine- associated seizures in a large, mostly pediatric population with sickling disorders. The results suggest that the incidence of seizures with meperidine is extremely small (0.4% of patients; 0.06% of admissions). The risk of seizures should not dissuade clinicians from using this drug.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalClinical Pediatrics
Issue number8
StatePublished - 1999


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