Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients

Transfusion Safety Study Group

Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients

Transfusion Safety Study Group

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HTLV) at that time. They and their recipients have been traced for additional HTLV studies. Immunophenotypic analyses of peripheral blood lymphocytes from nine antiHTLV-positive recipients, assumed to be infected during or since late 1984, showed no significant changes from healthy controls. Evaluation of the immunophenotypes of the 48 donors, however, showed significant elevations in the absolute counts of the T-cell (CD2) and natural killer (CD56) populations, the T helper/inducer and suppressor/inducer subsets (CD4⁺ CD29⁺ and CD4⁺ CD45RA⁺), and changes in T-cell activation markers. Long-term but not recent HTLV infection appears to alter the T-cell immunophenotypic pattern. Both infection with HTLV and human immunodeficiency virus type 1 are associated with a decreased CD2⁺ CD26⁺ count.

Original language	English
Pages (from-to)	628-632
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	4
Issue number	6
State	Published - Jun 1991

Keywords

Blood donors
Blood transfusion
Human T-cell lymphotrophic virus infection
T-lymphocytes

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@article{f3a1af78758148bda2b4a4c5ddb48791,

title = "Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients",

abstract = "The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HTLV) at that time. They and their recipients have been traced for additional HTLV studies. Immunophenotypic analyses of peripheral blood lymphocytes from nine antiHTLV-positive recipients, assumed to be infected during or since late 1984, showed no significant changes from healthy controls. Evaluation of the immunophenotypes of the 48 donors, however, showed significant elevations in the absolute counts of the T-cell (CD2) and natural killer (CD56) populations, the T helper/inducer and suppressor/inducer subsets (CD4+ CD29+ and CD4+ CD45RA+), and changes in T-cell activation markers. Long-term but not recent HTLV infection appears to alter the T-cell immunophenotypic pattern. Both infection with HTLV and human immunodeficiency virus type 1 are associated with a decreased CD2+ CD26+ count.",

keywords = "Blood donors, Blood transfusion, Human T-cell lymphotrophic virus infection, T-lymphocytes",

author = "{Transfusion Safety Study Group} and Fletcher, {Mary A.} and Gjerset, {George F.} and Joseph Hassett and Elizabeth Donegan and Parker, {John W.} and Mosley, {James W.} and Mosley, {J. W.} and Bregman, {D. J.} and Dougherty, {M. F.} and J. Gaiennie and Johnson, {C. S.} and Kasper, {C. K.} and H. Lee and Operskalski, {E. A.} and Parker, {J. W.} and Powars, {D. R.} and M. Stuart and E. Taylor-Munoz and Kleinman and C. Hyman and Dietrich, {S. L.} and Lusher, {J. M.} and J. Kaplan and S. Sarnaik and Schiff, {E. R.} and {De Medina}, M. and Fletcher, {M. A.} and Lian, {E. C.} and Pegelow, {C. H.} and Reddy, {K. R.} and Temple, {J. D.} and S. Toledano and Tomasulo and Aledort, {L. M.} and J. Hassett and H. Sacks and P. Wiesen and Hilgartner, {M. W.} and Stevens, {C. F.} and Taylor, {P. E.} and Kaufman, {M. F.} and Y. Kulpa and Brown and Miller and E. Donegan and Koerper, {M. A.} and K. Miller and Stites, {D. P.} and Vyas, {G. N.} and Perkins, {H. A.}",

year = "1991",

month = jun,

language = "English",

volume = "4",

pages = "628--632",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

number = "6",

}

TY - JOUR

T1 - Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients

AU - Transfusion Safety Study Group

AU - Fletcher, Mary A.

AU - Gjerset, George F.

AU - Hassett, Joseph

AU - Donegan, Elizabeth

AU - Parker, John W.

AU - Mosley, James W.

AU - Mosley, J. W.

AU - Bregman, D. J.

AU - Dougherty, M. F.

AU - Gaiennie, J.

AU - Johnson, C. S.

AU - Kasper, C. K.

AU - Lee, H.

AU - Operskalski, E. A.

AU - Parker, J. W.

AU - Powars, D. R.

AU - Stuart, M.

AU - Taylor-Munoz, E.

AU - Kleinman,

AU - Hyman, C.

AU - Dietrich, S. L.

AU - Lusher, J. M.

AU - Kaplan, J.

AU - Sarnaik, S.

AU - Schiff, E. R.

AU - De Medina, M.

AU - Fletcher, M. A.

AU - Lian, E. C.

AU - Pegelow, C. H.

AU - Reddy, K. R.

AU - Temple, J. D.

AU - Toledano, S.

AU - Tomasulo,

AU - Aledort, L. M.

AU - Hassett, J.

AU - Sacks, H.

AU - Wiesen, P.

AU - Hilgartner, M. W.

AU - Stevens, C. F.

AU - Taylor, P. E.

AU - Kaufman, M. F.

AU - Kulpa, Y.

AU - Brown,

AU - Miller,

AU - Donegan, E.

AU - Koerper, M. A.

AU - Miller, K.

AU - Stites, D. P.

AU - Vyas, G. N.

AU - Perkins, H. A.

PY - 1991/6

Y1 - 1991/6

N2 - The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HTLV) at that time. They and their recipients have been traced for additional HTLV studies. Immunophenotypic analyses of peripheral blood lymphocytes from nine antiHTLV-positive recipients, assumed to be infected during or since late 1984, showed no significant changes from healthy controls. Evaluation of the immunophenotypes of the 48 donors, however, showed significant elevations in the absolute counts of the T-cell (CD2) and natural killer (CD56) populations, the T helper/inducer and suppressor/inducer subsets (CD4+ CD29+ and CD4+ CD45RA+), and changes in T-cell activation markers. Long-term but not recent HTLV infection appears to alter the T-cell immunophenotypic pattern. Both infection with HTLV and human immunodeficiency virus type 1 are associated with a decreased CD2+ CD26+ count.

AB - The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HTLV) at that time. They and their recipients have been traced for additional HTLV studies. Immunophenotypic analyses of peripheral blood lymphocytes from nine antiHTLV-positive recipients, assumed to be infected during or since late 1984, showed no significant changes from healthy controls. Evaluation of the immunophenotypes of the 48 donors, however, showed significant elevations in the absolute counts of the T-cell (CD2) and natural killer (CD56) populations, the T helper/inducer and suppressor/inducer subsets (CD4+ CD29+ and CD4+ CD45RA+), and changes in T-cell activation markers. Long-term but not recent HTLV infection appears to alter the T-cell immunophenotypic pattern. Both infection with HTLV and human immunodeficiency virus type 1 are associated with a decreased CD2+ CD26+ count.

KW - Blood donors

KW - Blood transfusion

KW - Human T-cell lymphotrophic virus infection

KW - T-lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=0026053086&partnerID=8YFLogxK

M3 - Article

C2 - 1673714

AN - SCOPUS:0026053086

VL - 4

SP - 628

EP - 632

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 6

ER -

Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients

Abstract

Keywords

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