Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Shanmuganathan Chandrakasan; Christine J. Ye; Meera Chitlur; Anwar N. Mohamed; Raja Rabah; Andre Konski; Henry H.Q. Heng; Süreyya Savaşan

doi:10.1002/pbc.22929

Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Shanmuganathan Chandrakasan, Christine J. Ye, Meera Chitlur, Anwar N. Mohamed, Raja Rabah, Andre Konski, Henry H.Q. Heng, Süreyya Savaşan

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15 Scopus citations

Abstract

Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.

Original language	English
Pages (from-to)	1143-1145
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	56
Issue number	7
DOIs	https://doi.org/10.1002/pbc.22929
State	Published - Jul 1 2011

Keywords

Autism
Autologous stem cell transplantation
Genomic instability
Hodgkin lymphoma
Malignant fibrous histiocytoma
Non-clonal chromosome aberration (NCCA)

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10.1002/pbc.22929

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abstract = "Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.",

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T2 - Evidence for genomic instability

AU - Chandrakasan, Shanmuganathan

AU - Ye, Christine J.

AU - Chitlur, Meera

AU - Mohamed, Anwar N.

AU - Rabah, Raja

AU - Konski, Andre

AU - Heng, Henry H.Q.

AU - Savaşan, Süreyya

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AB - Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.

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KW - Genomic instability

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KW - Non-clonal chromosome aberration (NCCA)

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JO - Pediatric Blood and Cancer

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Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Abstract

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