Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Shanmuganathan Chandrakasan, Christine J. Ye, Meera Chitlur, Anwar N. Mohamed, Raja Rabah, Andre Konski, Henry H.Q. Heng, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.

Original languageEnglish
Pages (from-to)1143-1145
Number of pages3
JournalPediatric Blood and Cancer
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • Autism
  • Autologous stem cell transplantation
  • Genomic instability
  • Hodgkin lymphoma
  • Malignant fibrous histiocytoma
  • Non-clonal chromosome aberration (NCCA)

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