TY - JOUR
T1 - Management of COVID-19 infection in organic acidemias
AU - Kaur, Shagun
AU - Campbell, Stephanie L.
AU - Stockton, David W.
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2021/6
Y1 - 2021/6
N2 - The COVID-19 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS-CoV-2 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID-19 infection. The SARS-CoV-2 virus does not appear to cause a more severe metabolic deterioration than is typical.
AB - The COVID-19 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS-CoV-2 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID-19 infection. The SARS-CoV-2 virus does not appear to cause a more severe metabolic deterioration than is typical.
KW - COVID-19
KW - SARS-CoV-2
KW - glutaric acidemia type 1
KW - pediatric
KW - propionic acidemia
UR - http://www.scopus.com/inward/record.url?scp=85102196411&partnerID=8YFLogxK
U2 - 10.1002/ajmg.a.62161
DO - 10.1002/ajmg.a.62161
M3 - Article
C2 - 33686767
AN - SCOPUS:85102196411
VL - 185
SP - 1854
EP - 1857
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 6
ER -