Management of COVID-19 infection in organic acidemias

Shagun Kaur, Stephanie L. Campbell, David W. Stockton

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The COVID-19 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS-CoV-2 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID-19 infection. The SARS-CoV-2 virus does not appear to cause a more severe metabolic deterioration than is typical.

Original languageEnglish
Pages (from-to)1854-1857
Number of pages4
JournalAmerican Journal of Medical Genetics, Part A
Volume185
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • glutaric acidemia type 1
  • pediatric
  • propionic acidemia

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