Abstract
Muscle denervation is thought to be an attribute of age-related muscle weakness. Oxida-tive stress associate with aging is one many mechanisms thought to promote age-related muscle denervation. It has been shown that mice lacking Cu/Zn superoxide dismutase (sod1) gene share many of the NMJ alterations observed in aging. Furthermore, mouse model of familial amyotrophic lateral sclerosis harboring transgenic mutant human sod1 display muscle denervation patterns similar to those observed in aging muscle. This re-view will highlight some of the research findings from mouse models of muscle denerva-tion that provide potential mechanistic insight into process regulating age-related mus-cle denervation.
| Original language | English |
|---|---|
| Pages (from-to) | 10 |
| Journal | Aging and Disease |
| Volume | 6 |
| Issue number | 6 |
| State | Published - May 7 2015 |