Mesenchymal stem cell-based therapy for ischemic stroke

Johnathon D. Anderson; Missy T. Pham; Zelenia Contreras; Madeline Hoon; Kyle D. Fink; Henrik J. Johansson; Julien Rossignol; Gary L. Dunbar; Megan Showalter; Oliver Fiehn; Charles S. Bramlett; Renee L. Bardini; Gerhard Bauer; Brian Fury; Kyle J. Hendrix; Frederic Chedin; Samir El-Andaloussi; Billianna Hwang; Michael S. Mulligan; Janne Lehtiö; Jan A. Nolta

doi:10.1186/s41016-016-0053-4

Mesenchymal stem cell-based therapy for ischemic stroke

Johnathon D. Anderson, Missy T. Pham, Zelenia Contreras, Madeline Hoon, Kyle D. Fink, Henrik J. Johansson, Julien Rossignol, Gary L. Dunbar, Megan Showalter, Oliver Fiehn, Charles S. Bramlett, Renee L. Bardini, Gerhard Bauer, Brian Fury, Kyle J. Hendrix, Frederic Chedin, Samir El-Andaloussi, Billianna Hwang, Michael S. Mulligan, Janne LehtiöJan A. Nolta

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

Original language	English
Article number	36
Journal	Chinese Neurosurgical Journal
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/s41016-016-0053-4
State	Published - Nov 1 2016

Keywords

Exosomes
Ischemic stroke
Mesenchymal stem cells

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10.1186/s41016-016-0053-4

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Anderson, J. D., Pham, M. T., Contreras, Z., Hoon, M., Fink, K. D., Johansson, H. J., Rossignol, J., Dunbar, G. L., Showalter, M., Fiehn, O., Bramlett, C. S., Bardini, R. L., Bauer, G., Fury, B., Hendrix, K. J., Chedin, F., El-Andaloussi, S., Hwang, B., Mulligan, M. S., ... Nolta, J. A. (2016). Mesenchymal stem cell-based therapy for ischemic stroke. Chinese Neurosurgical Journal, 2(1), Article 36. https://doi.org/10.1186/s41016-016-0053-4

@article{1f1850e8c4874f77b44f47e47866a925,

title = "Mesenchymal stem cell-based therapy for ischemic stroke",

abstract = "Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.",

keywords = "Exosomes, Ischemic stroke, Mesenchymal stem cells",

author = "Anderson, {Johnathon D.} and Pham, {Missy T.} and Zelenia Contreras and Madeline Hoon and Fink, {Kyle D.} and Johansson, {Henrik J.} and Julien Rossignol and Dunbar, {Gary L.} and Megan Showalter and Oliver Fiehn and Bramlett, {Charles S.} and Bardini, {Renee L.} and Gerhard Bauer and Brian Fury and Hendrix, {Kyle J.} and Frederic Chedin and Samir El-Andaloussi and Billianna Hwang and Mulligan, {Michael S.} and Janne Lehti{\"o} and Nolta, {Jan A.}",

note = "Funding Information: The authors are supported by NIH Transformative R01GM099688, NSF GRFP 2011116000, NIH T32-GM008799, NSF GROW 201111600, NIH T32-HL086350, NIH U2DK097154. Funding Information: The authors acknowledge the funding sources NIH Transformative R01GM099688, NSF GRFP 2011116000, NIH T32-GM008799, NSF GROW 201111600, NIH T32-HL086350, NIH U2DK097154. Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = nov,

day = "1",

doi = "10.1186/s41016-016-0053-4",

language = "English",

volume = "2",

journal = "Chinese Neurosurgical Journal",

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Anderson, JD, Pham, MT, Contreras, Z, Hoon, M, Fink, KD, Johansson, HJ, Rossignol, J , Dunbar, GL, Showalter, M, Fiehn, O, Bramlett, CS, Bardini, RL, Bauer, G, Fury, B, Hendrix, KJ, Chedin, F, El-Andaloussi, S, Hwang, B, Mulligan, MS, Lehtiö, J & Nolta, JA 2016, 'Mesenchymal stem cell-based therapy for ischemic stroke', Chinese Neurosurgical Journal, vol. 2, no. 1, 36. https://doi.org/10.1186/s41016-016-0053-4

TY - JOUR

T1 - Mesenchymal stem cell-based therapy for ischemic stroke

AU - Anderson, Johnathon D.

AU - Pham, Missy T.

AU - Contreras, Zelenia

AU - Hoon, Madeline

AU - Fink, Kyle D.

AU - Johansson, Henrik J.

AU - Rossignol, Julien

AU - Dunbar, Gary L.

AU - Showalter, Megan

AU - Fiehn, Oliver

AU - Bramlett, Charles S.

AU - Bardini, Renee L.

AU - Bauer, Gerhard

AU - Fury, Brian

AU - Hendrix, Kyle J.

AU - Chedin, Frederic

AU - El-Andaloussi, Samir

AU - Hwang, Billianna

AU - Mulligan, Michael S.

AU - Lehtiö, Janne

AU - Nolta, Jan A.

N1 - Funding Information: The authors are supported by NIH Transformative R01GM099688, NSF GRFP 2011116000, NIH T32-GM008799, NSF GROW 201111600, NIH T32-HL086350, NIH U2DK097154. Funding Information: The authors acknowledge the funding sources NIH Transformative R01GM099688, NSF GRFP 2011116000, NIH T32-GM008799, NSF GROW 201111600, NIH T32-HL086350, NIH U2DK097154. Publisher Copyright: © 2016 The Author(s).

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

AB - Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

KW - Exosomes

KW - Ischemic stroke

KW - Mesenchymal stem cells

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U2 - 10.1186/s41016-016-0053-4

DO - 10.1186/s41016-016-0053-4

M3 - Review article

AN - SCOPUS:85025126675

SN - 2057-4967

VL - 2

JO - Chinese Neurosurgical Journal

JF - Chinese Neurosurgical Journal

IS - 1

M1 - 36

ER -

Mesenchymal stem cell-based therapy for ischemic stroke

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Keywords

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