TY - JOUR
T1 - Metabolic effects of furaldehydes and impacts on biotechnological processes
AU - Almeida, J.
AU - Gorsich, Steven Ward
N1 - Funding Information:
Acknowledgements JA, MB, GL, and MFGG were financially supported by the Swedish Energy Agency. SG was financially supported by the Research Excellence Funds, ORSP, Central Michigan University.
PY - 2009/3
Y1 - 2009/3
N2 - There is a growing awareness that lignocellulosewill be a major raw material for production of both fuel andchemicals in the coming decades—most likely throughvarious fermentation routes. Considerable attention has beengiven to the problem of finding efficient means of separatingthe major constituents in lignocellulose (i.e., lignin, hemicellulose,and cellulose) and to efficiently hydrolyze thecarbohydrate parts into sugars. In these processes, byproductswill inevitably form to some extent, and these willhave to be dealt with in the ensuing microbial processes. Onegroup of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes—mostimportantly 5-hydroxymethyl-2-furaldehyde—are the dominantinhibitory compounds found in lignocellulosic hydrolyzates.The furaldehydes are known to have biologicaleffects and act as inhibitors in fermentation processes. Theeffects of these compounds will therefore have to beconsidered in the design of biotechnological processes usinglignocellulose. In this short review, we take a look at knownmetabolic effects, as well as strategies to overcome problemsin biotechnological applications caused by furaldehydes.
AB - There is a growing awareness that lignocellulosewill be a major raw material for production of both fuel andchemicals in the coming decades—most likely throughvarious fermentation routes. Considerable attention has beengiven to the problem of finding efficient means of separatingthe major constituents in lignocellulose (i.e., lignin, hemicellulose,and cellulose) and to efficiently hydrolyze thecarbohydrate parts into sugars. In these processes, byproductswill inevitably form to some extent, and these willhave to be dealt with in the ensuing microbial processes. Onegroup of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes—mostimportantly 5-hydroxymethyl-2-furaldehyde—are the dominantinhibitory compounds found in lignocellulosic hydrolyzates.The furaldehydes are known to have biologicaleffects and act as inhibitors in fermentation processes. Theeffects of these compounds will therefore have to beconsidered in the design of biotechnological processes usinglignocellulose. In this short review, we take a look at knownmetabolic effects, as well as strategies to overcome problemsin biotechnological applications caused by furaldehydes.
UR - https://www.springerlink.com/content/067j2878jq40174j/fulltext.pdf
M3 - Article
SN - 0175-7598
VL - 82
SP - 625
EP - 638
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 4
ER -