MICA * 008/A5. 1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality

Bai Sheng Huang, Qi Zhi Luo, Li Xin Li, Bing Mei, Yi Zhou Zou, Li Xiang Wu, Ping Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the relationship between MICA * 008/A5. 1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality. Methods: The MICA * 008/A5. 1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti - HCMV antibody IgM was detected in the serum by ELISA method. Results: The positive rate of MICA * 008/A5. 1 allele was significantly higher in the control group (56. 79%) than that in the kidney transplanted donee group (34.07%) (P < 0.05). The infection rate of HCMV in those individuals whose genotype was MICA * 008/A5. 1 (+) was significantly higher than that in the MICA * 008/A5. 1 (+). Conclusion: The individual whose genotype is MICA * 008/A5. 1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA * 008/A5. 1 (-) is liable to HCMV infection.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalJournal of Central South University (Medical Sciences)
Volume31
Issue number4
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • Human cytomegalovirus
  • Kidney transplantation
  • MICA gene

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