MICA * 008/A5. 1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality

Objective: To investigate the relationship between MICA * 008/A5. 1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality. Methods: The MICA * 008/A5. 1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti - HCMV antibody IgM was detected in the serum by ELISA method. Results: The positive rate of MICA * 008/A5. 1 allele was significantly higher in the control group (56. 79%) than that in the kidney transplanted donee group (34.07%) (P < 0.05). The infection rate of HCMV in those individuals whose genotype was MICA * 008/A5. 1 (+) was significantly higher than that in the MICA * 008/A5. 1 (+). Conclusion: The individual whose genotype is MICA * 008/A5. 1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA * 008/A5. 1 (-) is liable to HCMV infection.