TY - GEN
T1 - Mitigate hydrophobicity-induced immunogenicity using biocompatible sugar poly(Orthoester)
AU - Maiti, Sampa
AU - Manna, Saikat
AU - Shen, Jingjing
AU - Esser-Kahn, Aaron P.
AU - Du, Wenjun
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Nanoparticles (NPs) derived from amphiphilic polymers demonstrate great advantages in addressing critical problems in biomedical and pharmaceutic studies. However, their clinical applications are hardly realized. Among the many issues, the immunogenicity of the NPs remains one of the most prominent bottlenecks. Studies suggested that the hydrophobicity of the NP could the primary cause for the immunogenicity.[1-3] Thereby, most NP design involves the use of a camouflage, often, hydrophilic polyethylene glycol (PEG), to protect the hydrophobic component.[4] However, despite the use of camouflages, the NPs can still be identified by the immune systems. Recent studies suggested biomolecules can develop mechanisms to penetrate,[5] highlighting the importance of using biocompatible polymers as the hydrophobic component. We hypothesized that if biocompatible carbohydrate-based polymers was used as the hydrophobic component, NPs with low immunogenicity may be achieved.
AB - Nanoparticles (NPs) derived from amphiphilic polymers demonstrate great advantages in addressing critical problems in biomedical and pharmaceutic studies. However, their clinical applications are hardly realized. Among the many issues, the immunogenicity of the NPs remains one of the most prominent bottlenecks. Studies suggested that the hydrophobicity of the NP could the primary cause for the immunogenicity.[1-3] Thereby, most NP design involves the use of a camouflage, often, hydrophilic polyethylene glycol (PEG), to protect the hydrophobic component.[4] However, despite the use of camouflages, the NPs can still be identified by the immune systems. Recent studies suggested biomolecules can develop mechanisms to penetrate,[5] highlighting the importance of using biocompatible polymers as the hydrophobic component. We hypothesized that if biocompatible carbohydrate-based polymers was used as the hydrophobic component, NPs with low immunogenicity may be achieved.
UR - http://www.scopus.com/inward/record.url?scp=85065433164&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065433164
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 50
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -