Mitochondria in heart failure

Mariana G. Rosca, Charles L. Hoppel

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations

Abstract

This review focuses on the evidence accumulated in humans and animal models to the effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria are the primary source of energy in the form of adenosine triphosphate that fuels the contractile apparatus, and are thus essential for the pumping activity of the heart. We evaluate changes in mitochondrial morphology and alterations in the main components of mitochondrial energetics, such as substrate utilization and oxidative phosphorylation coupled with the level of respirasomes, in the context of their contribution to the chronic energy deficit and mechanical dysfunction in HF.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalCardiovascular Research
Volume88
Issue number1
DOIs
StatePublished - Oct 2010

Keywords

  • Heart failure
  • Mitochondria
  • Oxidative phsophorylation
  • Respirasomes
  • Reversible phosphorylation

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