Mitomycin, vindesine and cisplatin combination therapy in the treatment of advanced non-small cell lung cancer: A report of 108 cases

X. Zhang, Y. Sun, F. Feng

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To evaluate the results of combination chemotherapy with mitomycin (MMC), vindesine (VDS) and cisplatin (DDP) in patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 108 patients with advanced NSCLC was enrolled in this study. Adenocarcinoma (74 cases) and squamous-cell carcinoma (23 cases) were the most common type of malignancy. Thirty patients received prior chemotherapy while 78 did not. Results Complete response was observed in 1 patient and partial response in 36 patients with an overall response rate (RR) of 34.3%. The RR was significantly higher in the previously untreated patients (41.0%) and than that in the pretreated patients (P = 0. 0169). The RR did not significantly differ between patients with squamous - cell carcinoma (30.4%) and adenocarcinoma (32.4%). That of patients with metastases to the lymph nodes, to the other parts of lung, liver and bone was 43.1%, 32.4%, 25.0% and 0, respectively. The median response duration was 3 months and the median survival period was 7 months. The dose limiting toxicity was neutropenia, which was in grade III and IV in 41.7% of the treated patients. Grade III and IV thrombocytopenia was observed in 6.5% and grade III and IV nausea and vomiting in 21.3% of the treated patients. Conclusion A higher response rate is attainable in patients with advanced NSCLC treated by MMC, VDS and DDP with tolerable toxicity.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalZhonghua zhong liu za zhi [Chinese journal of oncology]
Volume21
Issue number3
StatePublished - 1999

Keywords

  • Carcinoma, non-small cell lung/drug therapy
  • Cisplatin
  • Lung neoplasms/drug therapy
  • Mitomycin
  • Vindesine

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