TY - JOUR
T1 - Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
AU - Maiti, Panchanan
AU - Manna, Jayeeta
AU - Ilavazhagan, G.
AU - Rossignol, Julien
AU - Dunbar, Gary L.
N1 - Funding Information:
Financial supports from Field Neurosciences Institute, St. Mary's of Michigan, USA, and Defence Research and Development Organization, Ministry of Defence, Government of India are acknowledged. We are thankful to Prof. Gal Bitan, University California Los Angeles, and Prof. Michael Patrick McDonald, University of Tennessee Health Science center for their help and supports.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The structure and dynamics of dendritic spines reflect the strength of synapses, which are severely affected in different brain diseases. Therefore, understanding the ultra-structure, molecular signaling mechanism(s) regulating dendritic spine dynamics is crucial. Although, since last century, dynamics of spine have been explored by several investigators in different neurological diseases, but despite countless efforts, a comprehensive understanding of the fundamental etiology and molecular signaling pathways involved in spine pathology is lacking. The purpose of this review is to provide a contextual framework of our current understanding of the molecular mechanisms of dendritic spine signaling, as well as their potential impact on different neurodegenerative and psychiatric diseases, as a format for highlighting some commonalities in function, as well as providing a format for new insights and perspectives into this critical area of research. Additionally, the potential strategies to restore spine structure-function in different diseases are also pointed out. Overall, these informations should help researchers to design new drugs to restore the structure-function of dendritic spine, a "hot site" of synaptic plasticity.
AB - The structure and dynamics of dendritic spines reflect the strength of synapses, which are severely affected in different brain diseases. Therefore, understanding the ultra-structure, molecular signaling mechanism(s) regulating dendritic spine dynamics is crucial. Although, since last century, dynamics of spine have been explored by several investigators in different neurological diseases, but despite countless efforts, a comprehensive understanding of the fundamental etiology and molecular signaling pathways involved in spine pathology is lacking. The purpose of this review is to provide a contextual framework of our current understanding of the molecular mechanisms of dendritic spine signaling, as well as their potential impact on different neurodegenerative and psychiatric diseases, as a format for highlighting some commonalities in function, as well as providing a format for new insights and perspectives into this critical area of research. Additionally, the potential strategies to restore spine structure-function in different diseases are also pointed out. Overall, these informations should help researchers to design new drugs to restore the structure-function of dendritic spine, a "hot site" of synaptic plasticity.
KW - Calcium signaling
KW - Dendritic spine
KW - Glutamate receptor
KW - Neurodegenerative diseases
KW - Psychiatric disorders
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=84947914117&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2015.09.020
DO - 10.1016/j.neubiorev.2015.09.020
M3 - Review article
C2 - 26562682
AN - SCOPUS:84947914117
VL - 59
SP - 208
EP - 237
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -