Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis

Xantha Karp, Iva Greenwald

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


HLH-2 is the Caenorhabditis elegans ortholog of the Drosophila Daughterless and mammalian E basic helix-loop-helix (bHLH) transcriptional activators that function during diverse events during animal development. HLH-2 has been implicated in cell fate specification in different neural lineages and in the LIN-12/Notch-mediated anchor cell (AC)/ventral uterine precursor cell (VU) decision in the somatic gonad. Here, we show that hlh-2 plays several distinct roles during somatic gonadogenesis. Our analysis suggests that hlh-2 is required to endow specific somatic gonadal cells with the competence to undergo the AC/VU decision, as well as functioning in the AC/VU decision per se; this novel "proAC" role appears to be analogous to the proneural role of Drosophila Daughterless. In addition to its two distinct roles in the specification of the AC, hlh-2 is also required for correct differentiation and function of the AC. hlh-2 also acts at an independent point in the gonadal lineage both to specify distal tip cells (DTCs) and in DTC differentiation and function.

Original languageEnglish
Pages (from-to)460-469
Number of pages10
JournalDevelopmental Biology
Issue number2
StatePublished - Aug 15 2004


  • Daughterless
  • HLH-2
  • LIN-12, Notch
  • Proneural


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