TY - JOUR
T1 - Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids
AU - Chawla, Sanjay
AU - Natarajan, Girija
AU - Chowdhury, Dhuly
AU - Das, Abhik
AU - Walsh, Michele
AU - Bell, Edward F.
AU - Laptook, Abbot R.
AU - Van Meurs, Krisa
AU - D'Angio, Carl T.
AU - Stoll, Barbara J.
AU - Demauro, Sara B.
AU - Shankaran, Seetha
N1 - Funding Information:
This work was supported by grants from Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Funding Information:
The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network’s Moderate Preterm Registry through cooperative agreements. While NICHD staff did have input into the study design, conduct, analysis, and manuscript drafting, the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2018 Thieme Medical Publishers Inc. All rights reserved.
PY - 2018/4/27
Y1 - 2018/4/27
N2 - Objective We aimed to compare the rates of surfactant treated respiratory disease and other neonatal morbidities among moderately preterm (MPT) infants exposed to no, partial, or a complete course of antenatal corticosteroids (ANS). Study Design This observational cohort study evaluated MPT infants (29 0/7 -33 6/7 weeks' gestational age), born between January 2012 and November 2013 and enrolled in the MPT Registry of the National Institute of Child Health and Human Development Neonatal Research Network. Results Data were available for 5,886 infants, including 676 with no exposure, 1225 with partial, and 3,985 with a complete course of ANS. Among no, partial, and complete ANS groups, respectively, there were significant differences in rates of delivery room resuscitation (4.1, 1.4, and 1.2%), surfactant-treated respiratory disease (26.5, 26.3, and 20%), and severe intracranial hemorrhage (3, 2, and 0.8%). Complete ANS course was associated with lower surfactant-treated respiratory disease, compared with partial ANS (odds ratio [OR] 0.62; 95% confidence interval [CI] 0.52-0.74), and no ANS groups (OR 0.52; 95% CI 0.41-0.66) on adjusted analysis. Conclusion In MPT infants, ANS exposure is associated with lower delivery room resuscitation, surfactant-treated respiratory disease, and severe intracranial hemorrhage; with the lowest frequency of morbidities associated with a complete course.
AB - Objective We aimed to compare the rates of surfactant treated respiratory disease and other neonatal morbidities among moderately preterm (MPT) infants exposed to no, partial, or a complete course of antenatal corticosteroids (ANS). Study Design This observational cohort study evaluated MPT infants (29 0/7 -33 6/7 weeks' gestational age), born between January 2012 and November 2013 and enrolled in the MPT Registry of the National Institute of Child Health and Human Development Neonatal Research Network. Results Data were available for 5,886 infants, including 676 with no exposure, 1225 with partial, and 3,985 with a complete course of ANS. Among no, partial, and complete ANS groups, respectively, there were significant differences in rates of delivery room resuscitation (4.1, 1.4, and 1.2%), surfactant-treated respiratory disease (26.5, 26.3, and 20%), and severe intracranial hemorrhage (3, 2, and 0.8%). Complete ANS course was associated with lower surfactant-treated respiratory disease, compared with partial ANS (odds ratio [OR] 0.62; 95% confidence interval [CI] 0.52-0.74), and no ANS groups (OR 0.52; 95% CI 0.41-0.66) on adjusted analysis. Conclusion In MPT infants, ANS exposure is associated with lower delivery room resuscitation, surfactant-treated respiratory disease, and severe intracranial hemorrhage; with the lowest frequency of morbidities associated with a complete course.
KW - antenatal steroids
KW - gestational age
KW - intracranial hemorrhage
KW - necrotizing enterocolitis
KW - surfactant
UR - http://www.scopus.com/inward/record.url?scp=85046097447&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1642059
DO - 10.1055/s-0038-1642059
M3 - Article
C2 - 29702710
AN - SCOPUS:85046097447
VL - 35
SP - 1213
EP - 1221
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 12
ER -