Neurophotonic tools for microscopic measurements and manipulation: status report

Ahmed S. Abdelfattah; Sapna Ahuja; Taner Akkin; Srinivasa Rao Allu; Joshua Brake; David A. Boas; Erin M. Buckley; Robert E. Campbell; Anderson I. Chen; Xiaojun Cheng; Tom Ci m r; Irene Costantini; Massimo De Vittorio; Anna Devor; Patrick R. Doran; Mirna El Khatib; Valentina Emiliani; Natalie Fomin-Thunemann; Yeshaiahu Fainman; Tomas Fernandez-Alfonso; Christopher G.L. Ferri; Ariel Gilad; Xue Han; Andrew Harris; Elizabeth M.C. Hillman; Ute Hochgeschwender; Matthew G. Holt; Na Ji; Klvllclm Klllç; Evelyn M.R. Lake; Lei Li; Tianqi Li; Philipp MäcHler; Evan W. Miller; Rickson C. Mesquita; K. M.Naga Srinivas Nadella; U. Valentin Nägerl; Yusuke Nasu; Axel Nimmerjahn; Petra Ondráčková; Francesco S. Pavone; Citlali Perez Campos; Darcy S. Peterka; Filippo Pisano; Ferruccio Pisanello; Francesca Puppo; Bernardo L. Sabatini; Sanaz Sadegh; Sava Sakadzic; Shy Shoham; Sanaya N. Shroff; R. Angus Silver; Ruth R. Sims; Spencer L. Smith; Vivek J. Srinivasan; Martin Thunemann; Lei Tian; Lin Tian; Thomas Troxler; Antoine Valera; Alipasha Vaziri; Sergei A. Vinogradov; Flavia Vitale; Lihong V. Wang; Hana Uhlírová; Chris Xu; Changhuei Yang; Mu Han Yang; Gary Yellen; Ofer Yizhar; Yongxin Zhao

doi:10.1117/1.NPh.9.S1.013001

Neurophotonic tools for microscopic measurements and manipulation: status report

Ahmed S. Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David A. Boas, Erin M. Buckley, Robert E. Campbell, Anderson I. Chen, Xiaojun Cheng, Tom Ci m r, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick R. Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-AlfonsoChristopher G.L. Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth M.C. Hillman, Ute Hochgeschwender, Matthew G. Holt, Na Ji, Klvllclm Klllç, Evelyn M.R. Lake, Lei Li, Tianqi Li, Philipp MäcHler, Evan W. Miller, Rickson C. Mesquita, K. M.Naga Srinivas Nadella, U. Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco S. Pavone, Citlali Perez Campos, Darcy S. Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo L. Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya N. Shroff, R. Angus Silver, Ruth R. Sims, Spencer L. Smith, Vivek J. Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei A. Vinogradov, Flavia Vitale, Lihong V. Wang, Hana Uhlírová, Chris Xu, Changhuei Yang, Mu Han Yang, Gary Yellen, Ofer Yizhar, Yongxin Zhao

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.

Original language	English
Pages (from-to)	13001
Number of pages	1
Journal	Neurophotonics
Volume	9
Issue number	S1
DOIs	https://doi.org/10.1117/1.NPh.9.S1.013001
State	Published - Jan 1 2022

Keywords

blood flow
fluorescence
label free
molecular sensors
multimodal
optical imaging
optogenetics

Access to Document

10.1117/1.NPh.9.S1.013001

Cite this

Abdelfattah, A. S., Ahuja, S., Akkin, T., Allu, S. R., Brake, J., Boas, D. A., Buckley, E. M., Campbell, R. E., Chen, A. I., Cheng, X., Ci m r, T., Costantini, I., De Vittorio, M., Devor, A., Doran, P. R., El Khatib, M., Emiliani, V., Fomin-Thunemann, N., Fainman, Y., ... Zhao, Y. (2022). Neurophotonic tools for microscopic measurements and manipulation: status report. Neurophotonics, 9(S1), 13001. https://doi.org/10.1117/1.NPh.9.S1.013001

@article{31ceedc60c6b488690b76b0abec98adc,

title = "Neurophotonic tools for microscopic measurements and manipulation: status report",

abstract = "Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.",

keywords = "blood flow, fluorescence, label free, molecular sensors, multimodal, optical imaging, optogenetics",

author = "Abdelfattah, {Ahmed S.} and Sapna Ahuja and Taner Akkin and Allu, {Srinivasa Rao} and Joshua Brake and Boas, {David A.} and Buckley, {Erin M.} and Campbell, {Robert E.} and Chen, {Anderson I.} and Xiaojun Cheng and {Ci m r}, Tom and Irene Costantini and {De Vittorio}, Massimo and Anna Devor and Doran, {Patrick R.} and {El Khatib}, Mirna and Valentina Emiliani and Natalie Fomin-Thunemann and Yeshaiahu Fainman and Tomas Fernandez-Alfonso and Ferri, {Christopher G.L.} and Ariel Gilad and Xue Han and Andrew Harris and Hillman, {Elizabeth M.C.} and Ute Hochgeschwender and Holt, {Matthew G.} and Na Ji and Klvllclm Klll{\c c} and Lake, {Evelyn M.R.} and Lei Li and Tianqi Li and Philipp M{\"a}cHler and Miller, {Evan W.} and Mesquita, {Rickson C.} and Nadella, {K. M.Naga Srinivas} and N{\"a}gerl, {U. Valentin} and Yusuke Nasu and Axel Nimmerjahn and Petra Ondr{\'a}{\v c}kov{\'a} and Pavone, {Francesco S.} and {Perez Campos}, Citlali and Peterka, {Darcy S.} and Filippo Pisano and Ferruccio Pisanello and Francesca Puppo and Sabatini, {Bernardo L.} and Sanaz Sadegh and Sava Sakadzic and Shy Shoham and Shroff, {Sanaya N.} and Silver, {R. Angus} and Sims, {Ruth R.} and Smith, {Spencer L.} and Srinivasan, {Vivek J.} and Martin Thunemann and Lei Tian and Lin Tian and Thomas Troxler and Antoine Valera and Alipasha Vaziri and Vinogradov, {Sergei A.} and Flavia Vitale and Wang, {Lihong V.} and Hana Uhl{\'i}rov{\'a} and Chris Xu and Changhuei Yang and Yang, {Mu Han} and Gary Yellen and Ofer Yizhar and Yongxin Zhao",

note = "Funding Information: This report was edited by Anna Devor and Darcy Peterka. Cover design by Kivilcim Kili . A.D. was supported by the U.S. National Institutes of Health (NIH) grants R01MH111359, R01DA050159, and U19NS123717. A.N. was supported by NIH grants R01NS108034, U19NS112959, and U19NS123719. D.A.B. was supported by NIH grant R01NS108472. M.G.H. is currently the ERANet Chair (NCBio) at i3S Porto funded by the European Commission (H2020-WIDESPREAD-2018-2020-6; NCBio; 951923). R.A.S. is a Wellcome Principal Research Fellow (203048, 224499) and his microscopy development is co-funded by the NIH Brain initiative (U01NS113273). Fi.P., and Fe.P. acknowledge funding from the European Research Council under the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 677683. M.D.V. and Fe.P. acknowledge funding from the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 828972. Fi.P., M.D.V., Fe.P, O.Y., V.E., and T.C. acknowledge that this project has received funding from the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 101016787. Fe.P., B.L.S., and M.D.V. were funded by NIH Grant No. 1UF1NS108177-01. O.Y. and V. E. were supported by H2020-RIA (DEEPER 101016787) and the ERC (PrefrontalMap 819496). L.V.W. acknowledges funding support by NIH grants R01 NS102213, U01 NS099717, and U01 EB029823. S.L.S. was supported by NIH grants R01NS091335, R01NS121919 and National Science Foundation (NSF) grant 1934288. R.E.C, and Y.N. were supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant 19H05633. V.J.S. was supported by NIH grants NS094681, EB029747, and EY031469. S.N.S. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS115421). P.R.D. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS118949). T.A. and T.L. acknowledge funding from the University of Minnesota Medical School (AIRP) and the National Ataxia Foundation. F.V. was supported by NIH grants R01NS117756 and R01NS121219. U.H. was supported by NIH Brain Initiative grants R01NS120832, U01NS099709, and NSF NeuroNex Technology Hub 1707352. G.Y. was supported by NIH grants R01 GM124038 and R01 NS102586. L. T. was funded by NIH grant R21EY030016. I.C. was supported by European Union s Horizon 2020 Research and Innovation Framework Program under Grant Agreement No. 654148 (Laserlab-Europe); European Union s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3); General Hospital Corporation Center of the NIH under Award No. U01 MH117023; Italian Ministry for Education in the framework of Euro-Bioimaging Italian Node (ESFRI research infrastructure); {"}Fondazione CR Firenze{"} (private foundation). T. C., H. U., and P. O. were supported by the European Union s H2020-RIA (DEEPER, Grant Agreement No. 101016787), European Research Council (724530), and MEYS (CZ.02.1.01/ 0.0/ 0.0/ 15_003/0000476). S.S. was supported by NIH grants U19NS107464, R01NS109885 and UF1NS107680. V.E and R.S were supported by the European Research Council (ERC-2019-AdG 885090, HOLOVIS). N.J. was supported by NIH grant U01NS118300. A.V. was supported by the National Institute of Neurological Disorders and Stroke of the NIH under Award Nos. 5U01NS103488, 1RF1NS113251, and 1RF1NS110501, and the Kavli Foundation. D. S. P. was supported by NIH grants 5U19NS104649, 5U01NS113273, 9R44MH117430. Y. Z. was supported by NIH Director s New Innovator Award DP2 OD025926-01 and the Kaufman Foundation. A. S. A holds a Career Award at the Scientific Interface from Burroughs Wellcome Fund and acknowledges funding from the Searle Scholar Program and NIH New innovator award 1DP2MH129956. E. M. R. L. was supported by NIH grants R01MH111424 and U01NS094358. E. W. M. acknowledges support from NIH (R01NS098088) and NSF (NeuroNex 1707350). Funding Information: This report was edited by Anna Devor and Darcy Peterka. Cover design by Kıvılcım Kılı{\c c}. A.D. was supported by the U.S. National Institutes of Health (NIH) grants R01MH111359, R01DA050159, and U19NS123717. A.N. was supported by NIH grants R01NS108034, U19NS112959, and U19NS123719. D.A.B. was supported by NIH grant R01NS108472. M.G.H. is currently the ERANet Chair (NCBio) at i3S Porto funded by the European Commission (H2020-WIDESPREAD-2018-2020-6; NCBio; 951923). R.A.S. is a Wellcome Principal Research Fellow (203048, 224499) and his microscopy development is co-funded by the NIH Brain initiative (U01NS113273). Fi.P., and Fe.P. acknowledge funding from the European Research Council under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Program under Grant Agreement No. 677683. M.D.V. and Fe.P. acknowledge funding from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Program under Grant Agreement No. 828972. Fi.P., M.D.V., Fe.P, O.Y., V.E., and T.C. acknowledge that this project has received funding from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Program under Grant Agreement No. 101016787. Fe.P., B.L.S., and M.D.V. were funded by NIH Grant No. 1UF1NS108177-01. O.Y. and V. E. were supported by H2020-RIA (DEEPER 101016787) and the ERC (PrefrontalMap 819496). L.V.W. acknowledges funding support by NIH grants R01 NS102213, U01 NS099717, and U01 EB029823. S.L.S. was supported by NIH grants R01NS091335, R01NS121919 and National Science Foundation (NSF) grant 1934288. R.E.C, and Y.N. were supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant 19H05633. V.J.S. was supported by NIH grants NS094681, EB029747, and EY031469. S.N.S. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS115421). P.R.D. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS118949). T.A. and T.L. acknowledge funding from the University of Minnesota Medical School (AIRP) and the National Ataxia Foundation. F.V. was supported by NIH grants R01NS117756 and R01NS121219. U.H. was supported by NIH Brain Initiative grants R01NS120832, U01NS099709, and NSF NeuroNex Technology Hub 1707352. G.Y. was supported by NIH grants R01 GM124038 and R01 NS102586. L. T. was funded by NIH grant R21EY030016. I.C. was supported by European Union{\textquoteright}s Horizon 2020 Research and Innovation Framework Program under Grant Agreement No. 654148 (Laserlab-Europe); European Union{\textquoteright}s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3); General Hospital Corporation Center of the NIH under Award No. U01 MH117023; Italian Ministry for Education in the framework of Euro-Bioimaging Italian Node (ESFRI research infrastructure); “Fondazione CR Firenze” (private foundation). T. {\v C}., H. U., and P. O. were supported by the European Union{\textquoteright}s H2020-RIA (DEEPER, Grant Agreement No. 101016787), European Research Council (724530), and MEYS (CZ.02.1.01/ 0.0/ 0.0/ 15_003/0000476). S.S. was supported by NIH grants U19NS107464, R01NS109885 and UF1NS107680. V.E and R.S were supported by the European Research Council (ERC-2019-AdG 885090, HOLOVIS). N.J. was supported by NIH grant U01NS118300. A.V. was supported by the National Institute of Neurological Disorders and Stroke of the NIH under Award Nos. 5U01NS103488, 1RF1NS113251, and 1RF1NS110501, and the Kavli Foundation. D. S. P. was supported by NIH grants 5U19NS104649, 5U01NS113273, 9R44MH117430. Y. Z. was supported by NIH Director{\textquoteright}s New Innovator Award DP2 OD025926-01 and the Kaufman Foundation. A. S. A holds a Career Award at the Scientific Interface from Burroughs Wellcome Fund and acknowledges funding from the Searle Scholar Program and NIH New innovator award 1DP2MH129956. E. M. R. L. was supported by NIH grants R01MH111424 and U01NS094358. E. W. M. acknowledges support from NIH (R01NS098088) and NSF (NeuroNex 1707350). Publisher Copyright: {\textcopyright} The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.",

year = "2022",

month = jan,

day = "1",

doi = "10.1117/1.NPh.9.S1.013001",

language = "English",

volume = "9",

pages = "13001",

journal = "Neurophotonics",

issn = "2329-423X",

number = "S1",

}

Abdelfattah, AS, Ahuja, S, Akkin, T, Allu, SR, Brake, J, Boas, DA, Buckley, EM, Campbell, RE, Chen, AI, Cheng, X, Ci m r, T, Costantini, I, De Vittorio, M, Devor, A, Doran, PR, El Khatib, M, Emiliani, V, Fomin-Thunemann, N, Fainman, Y, Fernandez-Alfonso, T, Ferri, CGL, Gilad, A, Han, X, Harris, A, Hillman, EMC, Hochgeschwender, U, Holt, MG, Ji, N, Klllç, K, Lake, EMR, Li, L, Li, T, MäcHler, P, Miller, EW, Mesquita, RC, Nadella, KMNS, Nägerl, UV, Nasu, Y, Nimmerjahn, A, Ondráčková, P, Pavone, FS, Perez Campos, C, Peterka, DS, Pisano, F, Pisanello, F, Puppo, F, Sabatini, BL, Sadegh, S, Sakadzic, S, Shoham, S, Shroff, SN, Silver, RA, Sims, RR, Smith, SL, Srinivasan, VJ, Thunemann, M, Tian, L, Tian, L, Troxler, T, Valera, A, Vaziri, A, Vinogradov, SA, Vitale, F, Wang, LV, Uhlírová, H, Xu, C, Yang, C, Yang, MH, Yellen, G, Yizhar, O & Zhao, Y 2022, 'Neurophotonic tools for microscopic measurements and manipulation: status report', Neurophotonics, vol. 9, no. S1, pp. 13001. https://doi.org/10.1117/1.NPh.9.S1.013001

TY - JOUR

T1 - Neurophotonic tools for microscopic measurements and manipulation

T2 - status report

AU - Abdelfattah, Ahmed S.

AU - Ahuja, Sapna

AU - Akkin, Taner

AU - Allu, Srinivasa Rao

AU - Brake, Joshua

AU - Boas, David A.

AU - Buckley, Erin M.

AU - Campbell, Robert E.

AU - Chen, Anderson I.

AU - Cheng, Xiaojun

AU - Ci m r, Tom

AU - Costantini, Irene

AU - De Vittorio, Massimo

AU - Devor, Anna

AU - Doran, Patrick R.

AU - El Khatib, Mirna

AU - Emiliani, Valentina

AU - Fomin-Thunemann, Natalie

AU - Fainman, Yeshaiahu

AU - Fernandez-Alfonso, Tomas

AU - Ferri, Christopher G.L.

AU - Gilad, Ariel

AU - Han, Xue

AU - Harris, Andrew

AU - Hillman, Elizabeth M.C.

AU - Hochgeschwender, Ute

AU - Holt, Matthew G.

AU - Ji, Na

AU - Klllç, Klvllclm

AU - Lake, Evelyn M.R.

AU - Li, Lei

AU - Li, Tianqi

AU - MäcHler, Philipp

AU - Miller, Evan W.

AU - Mesquita, Rickson C.

AU - Nadella, K. M.Naga Srinivas

AU - Nägerl, U. Valentin

AU - Nasu, Yusuke

AU - Nimmerjahn, Axel

AU - Ondráčková, Petra

AU - Pavone, Francesco S.

AU - Perez Campos, Citlali

AU - Peterka, Darcy S.

AU - Pisano, Filippo

AU - Pisanello, Ferruccio

AU - Puppo, Francesca

AU - Sabatini, Bernardo L.

AU - Sadegh, Sanaz

AU - Sakadzic, Sava

AU - Shoham, Shy

AU - Shroff, Sanaya N.

AU - Silver, R. Angus

AU - Sims, Ruth R.

AU - Smith, Spencer L.

AU - Srinivasan, Vivek J.

AU - Thunemann, Martin

AU - Tian, Lei

AU - Tian, Lin

AU - Troxler, Thomas

AU - Valera, Antoine

AU - Vaziri, Alipasha

AU - Vinogradov, Sergei A.

AU - Vitale, Flavia

AU - Wang, Lihong V.

AU - Uhlírová, Hana

AU - Xu, Chris

AU - Yang, Changhuei

AU - Yang, Mu Han

AU - Yellen, Gary

AU - Yizhar, Ofer

AU - Zhao, Yongxin

N1 - Funding Information: This report was edited by Anna Devor and Darcy Peterka. Cover design by Kivilcim Kili . A.D. was supported by the U.S. National Institutes of Health (NIH) grants R01MH111359, R01DA050159, and U19NS123717. A.N. was supported by NIH grants R01NS108034, U19NS112959, and U19NS123719. D.A.B. was supported by NIH grant R01NS108472. M.G.H. is currently the ERANet Chair (NCBio) at i3S Porto funded by the European Commission (H2020-WIDESPREAD-2018-2020-6; NCBio; 951923). R.A.S. is a Wellcome Principal Research Fellow (203048, 224499) and his microscopy development is co-funded by the NIH Brain initiative (U01NS113273). Fi.P., and Fe.P. acknowledge funding from the European Research Council under the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 677683. M.D.V. and Fe.P. acknowledge funding from the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 828972. Fi.P., M.D.V., Fe.P, O.Y., V.E., and T.C. acknowledge that this project has received funding from the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 101016787. Fe.P., B.L.S., and M.D.V. were funded by NIH Grant No. 1UF1NS108177-01. O.Y. and V. E. were supported by H2020-RIA (DEEPER 101016787) and the ERC (PrefrontalMap 819496). L.V.W. acknowledges funding support by NIH grants R01 NS102213, U01 NS099717, and U01 EB029823. S.L.S. was supported by NIH grants R01NS091335, R01NS121919 and National Science Foundation (NSF) grant 1934288. R.E.C, and Y.N. were supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant 19H05633. V.J.S. was supported by NIH grants NS094681, EB029747, and EY031469. S.N.S. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS115421). P.R.D. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS118949). T.A. and T.L. acknowledge funding from the University of Minnesota Medical School (AIRP) and the National Ataxia Foundation. F.V. was supported by NIH grants R01NS117756 and R01NS121219. U.H. was supported by NIH Brain Initiative grants R01NS120832, U01NS099709, and NSF NeuroNex Technology Hub 1707352. G.Y. was supported by NIH grants R01 GM124038 and R01 NS102586. L. T. was funded by NIH grant R21EY030016. I.C. was supported by European Union s Horizon 2020 Research and Innovation Framework Program under Grant Agreement No. 654148 (Laserlab-Europe); European Union s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3); General Hospital Corporation Center of the NIH under Award No. U01 MH117023; Italian Ministry for Education in the framework of Euro-Bioimaging Italian Node (ESFRI research infrastructure); "Fondazione CR Firenze" (private foundation). T. C., H. U., and P. O. were supported by the European Union s H2020-RIA (DEEPER, Grant Agreement No. 101016787), European Research Council (724530), and MEYS (CZ.02.1.01/ 0.0/ 0.0/ 15_003/0000476). S.S. was supported by NIH grants U19NS107464, R01NS109885 and UF1NS107680. V.E and R.S were supported by the European Research Council (ERC-2019-AdG 885090, HOLOVIS). N.J. was supported by NIH grant U01NS118300. A.V. was supported by the National Institute of Neurological Disorders and Stroke of the NIH under Award Nos. 5U01NS103488, 1RF1NS113251, and 1RF1NS110501, and the Kavli Foundation. D. S. P. was supported by NIH grants 5U19NS104649, 5U01NS113273, 9R44MH117430. Y. Z. was supported by NIH Director s New Innovator Award DP2 OD025926-01 and the Kaufman Foundation. A. S. A holds a Career Award at the Scientific Interface from Burroughs Wellcome Fund and acknowledges funding from the Searle Scholar Program and NIH New innovator award 1DP2MH129956. E. M. R. L. was supported by NIH grants R01MH111424 and U01NS094358. E. W. M. acknowledges support from NIH (R01NS098088) and NSF (NeuroNex 1707350). Funding Information: This report was edited by Anna Devor and Darcy Peterka. Cover design by Kıvılcım Kılıç. A.D. was supported by the U.S. National Institutes of Health (NIH) grants R01MH111359, R01DA050159, and U19NS123717. A.N. was supported by NIH grants R01NS108034, U19NS112959, and U19NS123719. D.A.B. was supported by NIH grant R01NS108472. M.G.H. is currently the ERANet Chair (NCBio) at i3S Porto funded by the European Commission (H2020-WIDESPREAD-2018-2020-6; NCBio; 951923). R.A.S. is a Wellcome Principal Research Fellow (203048, 224499) and his microscopy development is co-funded by the NIH Brain initiative (U01NS113273). Fi.P., and Fe.P. acknowledge funding from the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 677683. M.D.V. and Fe.P. acknowledge funding from the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 828972. Fi.P., M.D.V., Fe.P, O.Y., V.E., and T.C. acknowledge that this project has received funding from the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 101016787. Fe.P., B.L.S., and M.D.V. were funded by NIH Grant No. 1UF1NS108177-01. O.Y. and V. E. were supported by H2020-RIA (DEEPER 101016787) and the ERC (PrefrontalMap 819496). L.V.W. acknowledges funding support by NIH grants R01 NS102213, U01 NS099717, and U01 EB029823. S.L.S. was supported by NIH grants R01NS091335, R01NS121919 and National Science Foundation (NSF) grant 1934288. R.E.C, and Y.N. were supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant 19H05633. V.J.S. was supported by NIH grants NS094681, EB029747, and EY031469. S.N.S. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS115421). P.R.D. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS118949). T.A. and T.L. acknowledge funding from the University of Minnesota Medical School (AIRP) and the National Ataxia Foundation. F.V. was supported by NIH grants R01NS117756 and R01NS121219. U.H. was supported by NIH Brain Initiative grants R01NS120832, U01NS099709, and NSF NeuroNex Technology Hub 1707352. G.Y. was supported by NIH grants R01 GM124038 and R01 NS102586. L. T. was funded by NIH grant R21EY030016. I.C. was supported by European Union’s Horizon 2020 Research and Innovation Framework Program under Grant Agreement No. 654148 (Laserlab-Europe); European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3); General Hospital Corporation Center of the NIH under Award No. U01 MH117023; Italian Ministry for Education in the framework of Euro-Bioimaging Italian Node (ESFRI research infrastructure); “Fondazione CR Firenze” (private foundation). T. Č., H. U., and P. O. were supported by the European Union’s H2020-RIA (DEEPER, Grant Agreement No. 101016787), European Research Council (724530), and MEYS (CZ.02.1.01/ 0.0/ 0.0/ 15_003/0000476). S.S. was supported by NIH grants U19NS107464, R01NS109885 and UF1NS107680. V.E and R.S were supported by the European Research Council (ERC-2019-AdG 885090, HOLOVIS). N.J. was supported by NIH grant U01NS118300. A.V. was supported by the National Institute of Neurological Disorders and Stroke of the NIH under Award Nos. 5U01NS103488, 1RF1NS113251, and 1RF1NS110501, and the Kavli Foundation. D. S. P. was supported by NIH grants 5U19NS104649, 5U01NS113273, 9R44MH117430. Y. Z. was supported by NIH Director’s New Innovator Award DP2 OD025926-01 and the Kaufman Foundation. A. S. A holds a Career Award at the Scientific Interface from Burroughs Wellcome Fund and acknowledges funding from the Searle Scholar Program and NIH New innovator award 1DP2MH129956. E. M. R. L. was supported by NIH grants R01MH111424 and U01NS094358. E. W. M. acknowledges support from NIH (R01NS098088) and NSF (NeuroNex 1707350). Publisher Copyright: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.

AB - Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.

KW - blood flow

KW - fluorescence

KW - label free

KW - molecular sensors

KW - multimodal

KW - optical imaging

KW - optogenetics

UR - http://www.scopus.com/inward/record.url?scp=85129321141&partnerID=8YFLogxK

U2 - 10.1117/1.NPh.9.S1.013001

DO - 10.1117/1.NPh.9.S1.013001

M3 - Article

AN - SCOPUS:85129321141

SN - 2329-423X

VL - 9

SP - 13001

JO - Neurophotonics

JF - Neurophotonics

IS - S1

ER -

Neurophotonic tools for microscopic measurements and manipulation: status report

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this