TY - JOUR
T1 - Neuropsychological deficit profiles in systemic lupus erythematosus
AU - Johnstone, B
AU - Skeel, Reid Laughlin
N1 - Funding Information:
This article was funded in part by the National Institute of Child Health and Human Development, National Institutes of Health, under Grant 5 T32 HD07460-04. The opinions contained in this publication are those of the grantee and do not necessarily reflect those of the National Institutes of Health.
PY - 2000
Y1 - 2000
N2 - Although neuropsychological deficits have been reported in several cognitive domains in patients with systemic lupus erythematosus (SLE), there is considerable variability in the literature about which neuropsychological domains are most affected. Similar to studies that demonstrated that specific profiles of neuropsychological deficits exist for those with traumatic brain injury (TBI; Johnstone, Hexum, and Ashkanazi, 1995), this study examined whether a specific pattern of deficits is present in SLE. By comparing reading scores (as estimates of premorbid ability) to tests of concurrent cognitive abilities (i.e., memory, attention, etc.), it was determined that SLE presents a profile distinct from TBI, with the most significant impairments noted in expressive language (Z(diff) =-1.39), attention (Z(diff) =-0.41), and speed of processing (Z(diff) = -0.40). In contrast to TBI, no impairment was noted in intelligence, memory, or cognitive flexibility. Results suggest that memory problems reported by individuals with SLE may be related to inattention. Clinical implications are discussed.
AB - Although neuropsychological deficits have been reported in several cognitive domains in patients with systemic lupus erythematosus (SLE), there is considerable variability in the literature about which neuropsychological domains are most affected. Similar to studies that demonstrated that specific profiles of neuropsychological deficits exist for those with traumatic brain injury (TBI; Johnstone, Hexum, and Ashkanazi, 1995), this study examined whether a specific pattern of deficits is present in SLE. By comparing reading scores (as estimates of premorbid ability) to tests of concurrent cognitive abilities (i.e., memory, attention, etc.), it was determined that SLE presents a profile distinct from TBI, with the most significant impairments noted in expressive language (Z(diff) =-1.39), attention (Z(diff) =-0.41), and speed of processing (Z(diff) = -0.40). In contrast to TBI, no impairment was noted in intelligence, memory, or cognitive flexibility. Results suggest that memory problems reported by individuals with SLE may be related to inattention. Clinical implications are discussed.
M3 - Article
SN - 0908-4282
VL - 7
SP - 96
EP - 101
JO - Applied Neuropsychology
JF - Applied Neuropsychology
ER -