Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study

Cathy Buranahirun; Karin S. Walsh; Christine Mrakotsky; Stacy E. Croteau; Madhvi Rajpurkar; Susan Kearney; Cara Hannemann; Greta N. Wilkening; Kevin A. Shapiro; David L. Cooper

doi:10.1002/pbc.28004

Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study

Cathy Buranahirun, Karin S. Walsh, Christine Mrakotsky, Stacy E. Croteau, Madhvi Rajpurkar, Susan Kearney, Cara Hannemann, Greta N. Wilkening, Kevin A. Shapiro, David L. Cooper

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency virus had independent effects, and hemophilia negatively impacts academic achievement, attention, and behavior. The introduction of prophylaxis treatment in hemophilia has created the need for re-evaluation of the effects of hemophilia on neurodevelopment and cognition. We outline the Evolving Treatment of Hemophilia's Impact on Neurodevelopment, Intelligence, and Other Cognitive Functions (NCT03660774) study, which aims to meet this need.

Original language	English
Article number	e28004
Journal	Pediatric Blood and Cancer
Volume	67
Issue number	1
DOIs	https://doi.org/10.1002/pbc.28004
State	Published - Jan 1 2020

Keywords

HIV
hemophilia
neuroimaging
neurology
neuropsychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.28004

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Buranahirun, C., Walsh, K. S., Mrakotsky, C., Croteau, S. E., Rajpurkar, M., Kearney, S., Hannemann, C., Wilkening, G. N., Shapiro, K. A., & Cooper, D. L. (2020). Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study. Pediatric Blood and Cancer, 67(1), Article e28004. https://doi.org/10.1002/pbc.28004

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title = "Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study",

abstract = "Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency virus had independent effects, and hemophilia negatively impacts academic achievement, attention, and behavior. The introduction of prophylaxis treatment in hemophilia has created the need for re-evaluation of the effects of hemophilia on neurodevelopment and cognition. We outline the Evolving Treatment of Hemophilia's Impact on Neurodevelopment, Intelligence, and Other Cognitive Functions (NCT03660774) study, which aims to meet this need.",

keywords = "HIV, hemophilia, neuroimaging, neurology, neuropsychology",

author = "Cathy Buranahirun and Walsh, {Karin S.} and Christine Mrakotsky and Croteau, {Stacy E.} and Madhvi Rajpurkar and Susan Kearney and Cara Hannemann and Wilkening, {Greta N.} and Shapiro, {Kevin A.} and Cooper, {David L.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Pediatric Blood & Cancer Published byWiley Periodicals, Inc.",

year = "2020",

month = jan,

day = "1",

doi = "10.1002/pbc.28004",

language = "English",

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Buranahirun, C, Walsh, KS, Mrakotsky, C, Croteau, SE, Rajpurkar, M, Kearney, S, Hannemann, C, Wilkening, GN, Shapiro, KA & Cooper, DL 2020, 'Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study', Pediatric Blood and Cancer, vol. 67, no. 1, e28004. https://doi.org/10.1002/pbc.28004

TY - JOUR

T1 - Neuropsychological function in children with hemophilia

T2 - A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study

AU - Buranahirun, Cathy

AU - Walsh, Karin S.

AU - Mrakotsky, Christine

AU - Croteau, Stacy E.

AU - Rajpurkar, Madhvi

AU - Kearney, Susan

AU - Hannemann, Cara

AU - Wilkening, Greta N.

AU - Shapiro, Kevin A.

AU - Cooper, David L.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency virus had independent effects, and hemophilia negatively impacts academic achievement, attention, and behavior. The introduction of prophylaxis treatment in hemophilia has created the need for re-evaluation of the effects of hemophilia on neurodevelopment and cognition. We outline the Evolving Treatment of Hemophilia's Impact on Neurodevelopment, Intelligence, and Other Cognitive Functions (NCT03660774) study, which aims to meet this need.

AB - Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency virus had independent effects, and hemophilia negatively impacts academic achievement, attention, and behavior. The introduction of prophylaxis treatment in hemophilia has created the need for re-evaluation of the effects of hemophilia on neurodevelopment and cognition. We outline the Evolving Treatment of Hemophilia's Impact on Neurodevelopment, Intelligence, and Other Cognitive Functions (NCT03660774) study, which aims to meet this need.

KW - HIV

KW - hemophilia

KW - neuroimaging

KW - neurology

KW - neuropsychology

UR - http://www.scopus.com/inward/record.url?scp=85074054675&partnerID=8YFLogxK

U2 - 10.1002/pbc.28004

DO - 10.1002/pbc.28004

M3 - Review article

C2 - 31595670

AN - SCOPUS:85074054675

SN - 1545-5009

VL - 67

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 1

M1 - e28004

ER -

Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study

Abstract

Keywords

UN SDGs

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