TY - CHAP
T1 - New Insights into the Regulation of RNP Granule Assembly in Oocytes
AU - Schisa, Jennifer A.
N1 - Funding Information:
The author thanks Peter Boag, Florence Marlow, and Melissa Pepling for critical comments on the chapter and the members of the Schisa laboratory for helpful discussions and suggestions. This work was supported by NIH Grant 1 R15 GM93913-01 to J. Schisa.
PY - 2012
Y1 - 2012
N2 - In a variety of cell types in plants, animals, and fungi, ribonucleoprotein (RNP) complexes play critical roles in regulating RNA metabolism. These RNP granules include processing bodies and stress granules that are found broadly across cell types, as well as RNP granules unique to the germline, such as P granules, polar granules, sponge bodies, and germinal granules. This review focuses on RNP granules localized in oocytes of the major model systems, Caenorhabditis elegans, Drosophila, Xenopus, mouse, and zebrafish. The signature families of proteins within oocyte RNPs include Vasa and other RNA-binding proteins, decapping activators and enzymes, Argonaute family proteins, and translation initiation complex proteins. This review describes the many recent insights into the dynamics and functions of RNP granules, including their roles in mRNA degradation, mRNA localization, translational regulation, and fertility. The roles of the cytoskeleton and cell organelles in regulating RNP granule assembly are also discussed.
AB - In a variety of cell types in plants, animals, and fungi, ribonucleoprotein (RNP) complexes play critical roles in regulating RNA metabolism. These RNP granules include processing bodies and stress granules that are found broadly across cell types, as well as RNP granules unique to the germline, such as P granules, polar granules, sponge bodies, and germinal granules. This review focuses on RNP granules localized in oocytes of the major model systems, Caenorhabditis elegans, Drosophila, Xenopus, mouse, and zebrafish. The signature families of proteins within oocyte RNPs include Vasa and other RNA-binding proteins, decapping activators and enzymes, Argonaute family proteins, and translation initiation complex proteins. This review describes the many recent insights into the dynamics and functions of RNP granules, including their roles in mRNA degradation, mRNA localization, translational regulation, and fertility. The roles of the cytoskeleton and cell organelles in regulating RNP granule assembly are also discussed.
KW - Germ granules
KW - Oocytes
KW - P bodies
KW - P granules
KW - Polar granules
KW - RNP granules
KW - Sponge bodies
KW - Translational regulation
UR - http://www.scopus.com/inward/record.url?scp=84858837895&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-394306-4.00013-7
DO - 10.1016/B978-0-12-394306-4.00013-7
M3 - Chapter
AN - SCOPUS:84858837895
T3 - International Review of Cell and Molecular Biology
SP - 233
EP - 289
BT - International Review of Cell and Molecular Biology
PB - Elsevier Inc.
ER -