TY - JOUR
T1 - Null mutant mouse models of somatostatin and cortistatin, and their receptors
AU - Zeyda, T.
AU - Hochgeschwender, U.
PY - 2008/5/14
Y1 - 2008/5/14
N2 - Somatostatin (somatotropin release inhibitory factor, SRIF) and the related cortistatin (CST) are multifunctional peptide molecules attributed with neurohormone, neurotransmitter/modulator, and autocrine/paracrine actions. The physiological responses of SRIF and CST are mediated by five widely distributed G protein-coupled receptors (sst1-5) which have been implicated in regulating numerous biological processes. Much of the information on the effects of somatostatin has been gained through pharmacological studies with analogs and antagonists. The possibility of targeted mutagenesis in the mouse has resulted, over the last 10 years, in the generation of mouse models which genetically lack somatostatin ligands or receptors. We will review here the mouse models generated, the studies undertaken with them, and what has been learned so far.
AB - Somatostatin (somatotropin release inhibitory factor, SRIF) and the related cortistatin (CST) are multifunctional peptide molecules attributed with neurohormone, neurotransmitter/modulator, and autocrine/paracrine actions. The physiological responses of SRIF and CST are mediated by five widely distributed G protein-coupled receptors (sst1-5) which have been implicated in regulating numerous biological processes. Much of the information on the effects of somatostatin has been gained through pharmacological studies with analogs and antagonists. The possibility of targeted mutagenesis in the mouse has resulted, over the last 10 years, in the generation of mouse models which genetically lack somatostatin ligands or receptors. We will review here the mouse models generated, the studies undertaken with them, and what has been learned so far.
KW - Cortistatin
KW - Knock out
KW - Mice
KW - Null mutant
KW - Somatostatin
KW - Somatostatin receptor
UR - http://www.scopus.com/inward/record.url?scp=43549083516&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2007.11.029
DO - 10.1016/j.mce.2007.11.029
M3 - Article
C2 - 18206294
AN - SCOPUS:43549083516
VL - 286
SP - 18
EP - 25
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -