TY - JOUR
T1 - Nurses attitudes toward clinical research
T2 - Experience of the therapeutic hypothermia after pediatric cardiac arrest trials
AU - Browning, Brittan
AU - Page, Kent E.
AU - Kuhn, Renee L.
AU - DiLiberto, Mary Ann
AU - Deschenes, Jendar
AU - Taillie, Eileen
AU - Tomanio, Elyse
AU - Holubkov, Richard
AU - Dean, J. Michael
AU - Moler, Frank W.
AU - Meert, Kathleen
AU - Pemberton, Victoria L.
N1 - Funding Information:
The following clinical research coordinators and research nurses assisted with seeking and obtaining regulatory approval, communicated with the Data Coordinating Center, and acted as institutional champions for the study within their organization: Susan Velseco, Children''s Hospital at Montefiore; Margaret M. Villa, Children''s Hospital of Los Angeles and the UCLA; Cheryl Stone, Children''s Hospital of Atlanta; Ann Pawluszka, Children''s Hospital of Michigan; Mary Ann DiLiberto, Children''s Hospital of Philadelphia; Evin Golson, Children''s Medical Center Dallas; Jean Reardon and Elyse Tomanio, Children''s National Medical Center; Monica Weber, University of Michigan; Susan Bergant, Rainbow Babies and Children''s Hospital; Eileen Root Taillie, University of Rochester Medical Center; Jendar Deschenes, University of Arizona; Joan Diegel and Alan Abraham, University of Pittsburgh Medical Center; Holly Dibrell, University of Texas Health Centers at San Antonio; Lori Barganier, Washington University, St. Louis; and Mary Deherrera, Primary Children''s Hospital. These individuals received no compensation for their services. The Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) trials are sponsored by the National Heart, Lung, and Blood Institute (NHLBI) U01HL094345 (to Dr. Moler) and U01-HL094339 (to Dr. Dean). The funding source for the THAPCA trials had no role in the design and conduct of this study; collection, management, analysis, and interpretation of the data; preparation or review of the manuscript; and decision to submit the manuscript for publication. Dr. Browning received support for article research from the National Institutes of Health (NIH). Dr. Page received support for article research from the NIH. Dr. Kuhn received support for article research from the NIH. Her institution received financial support from the NHLBI. Dr. Tallie received support for article research from the NIH. Dr. Holubkov received financial support from Pfizer (consulting fees for DSMB membership), St. Jude Medical Inc. (biostatistical consulting), and Fibrocell Inc (DSMB member). He disclosed that he is also a biostatistical consultant for Physicians'' Committee for Responsible Medicine, a nonprofit in Washington, D.C. He received support for article research from the NIH. His institution received financial support from the NIH/NHLBI (this grant gave salary support to Dr. Holubkov as well as general support to the Coordinating Center). Dr. Dean received support for article research from the NIH. His institution received financial support from the NHLBI. Dr. Moler received support for article research from the NIH. His institution received financial support from the NIH/NHLBI (U01 awards to University of Michigan and University of Utah). Dr. Meert received support for article research from the NIH. Her institution received financial support from the NIH. Dr. Pemberton received support for article research from the Government. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Publisher Copyright:
© 2016 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
PY - 2016/3/23
Y1 - 2016/3/23
N2 - Objectives: To understand factors affecting nurses attitudes toward the Therapeutic Hypothermia After Pediatric Cardiac Arrest trials and association with approach/consent rates. Design: Cross-sectional survey of pediatric/cardiac intensive care nurses perceptions of the trials. Setting: Study was conducted at 16 of 38 self-selected study sites. Subjects: Pediatric and cardiac intensive care nurses. Measurements and Main Results: The primary outcome was the proportion of nurses with positive perceptions, as defined by agree or strongly agree with the statement "I am happy to take care of a Therapeutic Hypothermia after Pediatric Cardiac Arrest patient". Associations between perceptions and study approach/consent rates were also explored. Of 2,241 nurses invited, 1,387 (62%) completed the survey and 77% reported positive perceptions of the trials. Nurses, who felt positively about the scientific question, the study team, and training received, were more likely to have positive perceptions of the trials (p 0.001). Nurses who had previously cared for a research patient had significantly more positive perceptions of Therapeutic Hypothermia After Pediatric Cardiac Arrest compared with those who had not (79% vs 54%; p 0.001). Of the 754 nurses who cared for a Therapeutic Hypothermia After Pediatric Cardiac Arrest patient, 82% had positive perceptions, despite 86% reporting it required more work. Sixty-nine percent believed that hypothermia reduces brain injury and mortality; sites had lower consent rates when their nurses believed that hypothermia was beneficial. Institution-specific approach rates were positively correlated with nurses perceptions of institutional support for the trial (r = 0.54; p = 0.04), ICU support (r = 0.61; p = 0.02), and the importance of conducting the trial in children (r = 0.61; p = 0.01). Conclusions: The majority of nurses had positive perceptions of the Therapeutic Hypothermia After Pediatric Cardiac Arrest trials. Institutional, colleague, and study team support and training were contributing factors. Despite increased work, nurses remained enthusiastic demonstrating that studies with intensive bedside nursing procedures are feasible. Institutions whose nurses believed hypothermia was beneficial had lower consent rates, suggesting that educating nurses on study rationale and equipoise may enhance study participation.
AB - Objectives: To understand factors affecting nurses attitudes toward the Therapeutic Hypothermia After Pediatric Cardiac Arrest trials and association with approach/consent rates. Design: Cross-sectional survey of pediatric/cardiac intensive care nurses perceptions of the trials. Setting: Study was conducted at 16 of 38 self-selected study sites. Subjects: Pediatric and cardiac intensive care nurses. Measurements and Main Results: The primary outcome was the proportion of nurses with positive perceptions, as defined by agree or strongly agree with the statement "I am happy to take care of a Therapeutic Hypothermia after Pediatric Cardiac Arrest patient". Associations between perceptions and study approach/consent rates were also explored. Of 2,241 nurses invited, 1,387 (62%) completed the survey and 77% reported positive perceptions of the trials. Nurses, who felt positively about the scientific question, the study team, and training received, were more likely to have positive perceptions of the trials (p 0.001). Nurses who had previously cared for a research patient had significantly more positive perceptions of Therapeutic Hypothermia After Pediatric Cardiac Arrest compared with those who had not (79% vs 54%; p 0.001). Of the 754 nurses who cared for a Therapeutic Hypothermia After Pediatric Cardiac Arrest patient, 82% had positive perceptions, despite 86% reporting it required more work. Sixty-nine percent believed that hypothermia reduces brain injury and mortality; sites had lower consent rates when their nurses believed that hypothermia was beneficial. Institution-specific approach rates were positively correlated with nurses perceptions of institutional support for the trial (r = 0.54; p = 0.04), ICU support (r = 0.61; p = 0.02), and the importance of conducting the trial in children (r = 0.61; p = 0.01). Conclusions: The majority of nurses had positive perceptions of the Therapeutic Hypothermia After Pediatric Cardiac Arrest trials. Institutional, colleague, and study team support and training were contributing factors. Despite increased work, nurses remained enthusiastic demonstrating that studies with intensive bedside nursing procedures are feasible. Institutions whose nurses believed hypothermia was beneficial had lower consent rates, suggesting that educating nurses on study rationale and equipoise may enhance study participation.
KW - Heart arrest
KW - Nurses
KW - Pediatrics
KW - Perceptions
KW - Research
UR - http://www.scopus.com/inward/record.url?scp=84961214842&partnerID=8YFLogxK
U2 - 10.1097/PCC.0000000000000609
DO - 10.1097/PCC.0000000000000609
M3 - Article
C2 - 26669643
AN - SCOPUS:84961214842
VL - 17
SP - e121-e129
JO - Pediatric Critical Care Medicine
JF - Pediatric Critical Care Medicine
SN - 1529-7535
IS - 3
ER -