Outcomes after endovascular abdominal aortic aneurysm repair are equivalent between genders despite anatomic differences in women

Luc Dubois, Teresa V. Novick, Jeremy R. Harris, Guy Derose, Thomas L. Forbes

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: Prior work confirms gender-specific anatomic differences in patients undergoing endovascular aneurysm repair, but the clinical implications remain ill defined. The purpose of this study was to compare gender-specific early outcomes after endovascular aneurysm repair using a large international registry. Methods: Over the 2-year period ending in 2011, 1,262 patients (131 women, 10.4%; 1,131 men, 89.6%) with infrarenal aneurysms treated with the Endurant stent graft were prospectively enrolled in the ENGAGE registry and followed clinically and radiographically. Results: Women were older (75.5 ± 7.0 vs 72.8 ± 8.1; P =.0003) and had smaller aneurysms (57.8 ± 9.5 vs 60.6 ± 11.9 mm; P =.01). Women's infrarenal aortic necks were of narrower diameter (21.8 ± 3.4 vs 24.0 ± 3.5 mm; P < .0001), shorter length (24.3 ± 11.8 vs 27.3 ± 12.4 mm; P =.009), and greater angulation (37.7 ± 26.2° vs 29.4 ± 23.3°; P = .0002). More women had an infrarenal neck angle >60° (19.2% vs 9.1%; P =.001). Technical success was achieved in equal numbers of women and men (97.7% vs 99.2%; P =.10). On completion angiography, the incidence of any endoleak (21.5% vs 15.4%; P =.08) and type I endoleak (1.5% vs 1.1%; P =.60) did not differ between genders. At the 1-month follow-up, there were no differences between women and men with respect to endograft occlusion (2.5% vs 1.9%; P = .70), and differences observed in any endoleak (17.2% vs 11.4%; P =.08) and type I endoleaks (3.3% vs 1.2%; P = .08) did not reach statistical significance. Freedom from major adverse events was similar for women and men at 30 days (98.5% vs 95.8%; P =.23) and 1 year (85% vs 89.8%; P =.40). Survival at 30 days (100% vs 98.6%) and 1 year (92.5% vs 91.6%; P =.99) was similar for women and men. Conclusions: This large multinational registry confirms the previously observed prevalence of suboptimal neck anatomy in women. Even though women have shorter and more angulated infrarenal necks, their technical outcomes at 30 days and clinical outcomes at 1 year were similar to those of men. Much longer follow-up is necessary to determine whether these outcomes proved durable.

Original languageEnglish
Pages (from-to)382-389.e1
JournalJournal of Vascular Surgery
Issue number2
StatePublished - Feb 2013
Externally publishedYes


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