TY - JOUR
T1 - Parathyroid Hormone-Related Peptide
T2 - A Novel Endocrine Cardioprotective "conditioning Mimetic"
AU - Datta, Tanuka
AU - Przyklenk, Karin
AU - Datta, Nabanita S.
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/11/1
Y1 - 2017/11/1
N2 - An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones - in particular, parathyroid hormone-related peptide (PTHrP) - may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.
AB - An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones - in particular, parathyroid hormone-related peptide (PTHrP) - may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.
KW - heart
KW - ischemia
KW - mitogen-activated protein kinase phosphatase 1
KW - parathyroid hormone-related peptide
KW - reperfusion
UR - http://www.scopus.com/inward/record.url?scp=85032295671&partnerID=8YFLogxK
U2 - 10.1177/1074248417702976
DO - 10.1177/1074248417702976
M3 - Review article
C2 - 28403647
AN - SCOPUS:85032295671
SN - 1074-2484
VL - 22
SP - 529
EP - 537
JO - Journal of Cardiovascular Pharmacology and Therapeutics
JF - Journal of Cardiovascular Pharmacology and Therapeutics
IS - 6
ER -