Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children

Sabrina M. Heidemann, Alison Nair, Yonca Bulut, Anil Sapru

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Acute respiratory distress syndrome (ARDS) is a syndrome of noncardiogenic pulmonary edema and hypoxia that accompanies up to 30% of deaths in pediatric intensive care units. Pediatric ARDS (PARDS) is diagnosed by the presence of hypoxia, defined by oxygenation index or PaO2/FiO2 ratio cutoffs, and new chest infiltrate occurring within 7 days of a known insult. Hallmarks of ARDS include hypoxemia and decreased lung compliance, increased work of breathing, and impaired gas exchange. Mortality is often accompanied by multiple organ failure. Although many modalities to treat PARDS have been investigated, supportive therapies and lung protective ventilator support remain the mainstay.

Original languageEnglish
Pages (from-to)1017-1037
Number of pages21
JournalPediatric Clinics of North America
Issue number5
StatePublished - Oct 2017


  • Acute lung injury
  • Acute respiratory distress syndrome
  • Pathophysiology
  • Pediatrics


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