Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement

Bülent Özgönenel; Süreyya Savaşan; Raja Rabah; Anwar N. Mohamed; Barbara Cushing

doi:10.1080/10428190400018463

Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement

Bülent Özgönenel, Süreyya Savaşan, Raja Rabah, Anwar N. Mohamed, Barbara Cushing

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (TCHRLBCL) is a variant of large B-cell lymphoma only rarely encountered in children. Here we report the case of an 8-year-old African American boy with Epstein-Barr virus (EBV)-positive TCHRLBCL who initially presented with right submandibular, anterior cervical and supraclavicular lymphadenopathy. Cytogenetic analysis of the lymph node revealed a near-triploid karyotype with complex chromosomal aberrations. Although morphologically the bone marrow was normal, the same cytogenetically abnormal clone was detected. The patient responded to chemotherapy with CHOP (doxorubicin, cyclophosphamide, vincristine and prednisone) therapy, with disappearance of the abnormal clone from the bone marrow. The patient remains in remission 26 months after the initial diagnosis.

Original language	English
Pages (from-to)	465-469
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	46
Issue number	3
DOIs	https://doi.org/10.1080/10428190400018463
State	Published - Mar 2005

Keywords

Bone marrow involvement
Cytogenetics
T-cell/histiocyte-rich large B-cell lymphoma

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428190400018463

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title = "Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement",

abstract = "T-cell/histiocyte-rich large B-cell lymphoma (TCHRLBCL) is a variant of large B-cell lymphoma only rarely encountered in children. Here we report the case of an 8-year-old African American boy with Epstein-Barr virus (EBV)-positive TCHRLBCL who initially presented with right submandibular, anterior cervical and supraclavicular lymphadenopathy. Cytogenetic analysis of the lymph node revealed a near-triploid karyotype with complex chromosomal aberrations. Although morphologically the bone marrow was normal, the same cytogenetically abnormal clone was detected. The patient responded to chemotherapy with CHOP (doxorubicin, cyclophosphamide, vincristine and prednisone) therapy, with disappearance of the abnormal clone from the bone marrow. The patient remains in remission 26 months after the initial diagnosis.",

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AU - Özgönenel, Bülent

AU - Savaşan, Süreyya

AU - Rabah, Raja

AU - Mohamed, Anwar N.

AU - Cushing, Barbara

PY - 2005/3

Y1 - 2005/3

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AB - T-cell/histiocyte-rich large B-cell lymphoma (TCHRLBCL) is a variant of large B-cell lymphoma only rarely encountered in children. Here we report the case of an 8-year-old African American boy with Epstein-Barr virus (EBV)-positive TCHRLBCL who initially presented with right submandibular, anterior cervical and supraclavicular lymphadenopathy. Cytogenetic analysis of the lymph node revealed a near-triploid karyotype with complex chromosomal aberrations. Although morphologically the bone marrow was normal, the same cytogenetically abnormal clone was detected. The patient responded to chemotherapy with CHOP (doxorubicin, cyclophosphamide, vincristine and prednisone) therapy, with disappearance of the abnormal clone from the bone marrow. The patient remains in remission 26 months after the initial diagnosis.

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KW - Cytogenetics

KW - T-cell/histiocyte-rich large B-cell lymphoma

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Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement

Abstract

Keywords

UN SDGs

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