The flight duration of unmanned aerial vehicles (UAVs) is limited by their battery or fuel capacity. As a consequence, the duration of missions that can be pursued by UAVs without supporting logistics is restricted. However, a system of UAVs that is supported by automated logistics structures, such as fuel service stations and orchestration algorithms, may pursue missions of conceivably indefinite duration. This may be accomplished by handing off the mission tasks to fully fueled replacement UAVs when the current fleet grows weary. The drained UAVs then seek replenishment from nearby logistics support facilities. To support the vision of a persistent fleet of UAVs pursuing missions across a field of operations, we develop an improved mixed integer linear programming (MILP) model that can serve to support the system's efforts to orchestrate the operations of numerous UAVs, missions and logistics facilities. Further, we look toward the future implementation of such a persistent fleet out-doors and develop prototype components required for such a system. In particular, we develop and demonstrate the concerted operation of a scheduling model, UAV onboard vision-based guidance system and replenishment stations.